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SUMMARY:Structural and biochemical framework for CRISPR-Cas9 genome editin
 g
DTSTART:20161125T110000
DTEND:20161125T120000
DTSTAMP:20260406T222943Z
UID:92c257b1259fc9ebe7f09424536f7586227d0b71953a23bd6b45a16d
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Martin Jinek\nThe CRISPR-Cas9 system has emerged as a powe
 rful technology for modifying the genetic information in cells and organi
 sms. The CRISPR-associated protein Cas9 is an RNA-guided DNA nuclease tha
 t associates with an unusual dual-RNA guide structure and cleaves double-
 stranded DNA sequences complementary to a 20-nucleotide sequence in the 
 guide RNA. The enzyme can be programmed using single-molecule guide RNAs
  to induce double-strand DNA breaks in genomic DNA\, paving the way for R
 NA-guided genetic genome editing. Our current work focuses on obtaining 
 structural insights into the molecular function of Cas9. To this end\, we 
 have determined crystals structures of apo-Cas9 and Cas9 bound to a guide 
 RNA and a DNA target. The structures shed light on the molecular mechanism
  of Cas9-mediated DNA binding and cleavage and reveal the conformational 
 transitions occurring during the process. These studies provide the struc
 tural framework for the ongoing development of CRISPR-Cas9 for a new gener
 ation of genome editing tools and technologies.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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