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SUMMARY:Single Molecule Biophysics from Single Ions to Protein Clusters: W
 hen Less is More
DTSTART:20160616T171500
DTSTAMP:20260509T121826Z
UID:bd617f976efd36a4cb550a3e68ee5ae8ef5298c2f0d19f9729a988e3
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Aleksandra Radenovic\, Institute of Bioengineering\, EPF
 L\nINAUGURAL LECTUREAbstract:\nMany processes within the cell are carried 
 out by very few molecules. By studying single molecules\, it is possible t
 o obtain details about the mechanism of a reaction that cannot be ascertai
 ned by studying a population of molecules.Insights into complex behavior c
 an be gained through manipulation\, imaging or sensing of single biomolecu
 les.\nSingle-molecule techniques can provide us with extraordinarily clear
  and often surprising views of biomolecules in action. Development of appr
 opriate instrumentation has been identified as the key ingredient for adva
 nces in biophysical sciences. Three most important examples here are singl
 e molecule localization microscopy (SMLM)\, optical tweezers and nanopores
 . SMLM made it possible to "see" by visualizing single fluorophores in liv
 ing cells while laser-based optical tweezers allowed us to "touch" with ex
 periments on physical forces involved in stretching and binding of biomole
 cules\, while nanopores\, the simplest and the most recent single molecule
  technique allows for rapid and high-throughput biosensing and detection o
 f atto-molar molecule concentrations.We use novel solid state nanopore pla
 tform based on atomically thin nanopore membranes in 2D materials such as 
 graphene or molybdenum disulfide for DNA detection\, sequencing\, water de
 salination and osmotic power generation.Program:\n- Introduction by  Prof
 . Demetri Psaltis\, Dean of The School of engineering (STI)\n- Inaugural L
 ecture of Aleksandra Radenovic: "Single Molecule Biophysics from Single Io
 ns to Protein Clusters: When Less is More"\nPlease register here: http://g
 o.epfl.ch/radenovicBio:\nAleksandra Radenovic received her master's degree
  in physics from the University of Zagreb in 1999 before joining Professor
  Giovanni Dietler's Laboratory of Physics of Living Matter in 2000 at Univ
 ersity of Lausanne. There she earned her Doctor of Sciences degree in 2003
 . In 2003 she was also awarded a research scholarship for young researcher
 s from the Swiss Foundation for Scientific Research which allowed her to s
 pend 3 years as postdoctoral fellow at the University of California\, Berk
 eley (2004‐2007).\nBefore joining EPFL as Assistant Professor in 2008 sh
 e spent 6 months at NIH and Janelia Farm. In 2010 she received the ERC sta
 rting grant and in 2015 SNSF Consolidator grant. Her group is interested i
 n using novel nanomaterials and single molecule experimental techniques to
  study fundamental questions in molecular and cell biology.
LOCATION:CO2 http://map.epfl.ch/?room=co2
STATUS:CONFIRMED
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