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SUMMARY:The Lymphatic System in Disease Processes and Cancer Progression
DTSTART:20160428T161500
DTSTAMP:20260510T202414Z
UID:74bcf0ba7458fe82dd40957ec58dacd84780ee621cc6d7953d512f74
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Timothy P. Padera\, Massachusetts General Hospital & Har
 vard Medical School\, Boston\, MA (USA)\njoint CANCER & BIOENGINEERING SEM
 INARAbstract:\n(Background)\nMy laboratory uses novel intravital microscop
 y tools to examine how the lymphatic system can drive the progression of c
 ancer both through metastatic spread and impairment in anti-tumor immune f
 unction. In addition\, we study the molecular control of lymphatic pumping
  and how pumping becomes dysfunctional in variety of disease settings incl
 uding inflammation\, lymphedema and bacterial infection. Using our recentl
 y developed methods to longitudinally image lymph nodes in vivo\, we will 
 discuss our results showing that lymph node metastasis do not require the 
 formation of new blood vessels in order to grow. Additionally\, using our 
 recently developed optical method to measure lymph flow without requiring 
 injected contrast\, we will discuss the relationship between lymphatic pum
 ping\, lymph flow and intraluminal valve opening in collecting lymphatic v
 essels under normal and pathological conditions. By understanding the mole
 cular control of these processes\, the first drugs targeting lymphatic fun
 ction can be developed to help in the treatment of multiple diseases.Bio:\
 nDr. Padera earned Bachelor of Science degrees in both Chemical Engineerin
 g and Biomedical Engineering from Northwestern University in 1997. He then
  received his PhD from MIT in 2003 in Medical Engineering from the Harvard
 -MIT Division of Health Sciences and Technology under the supervision of R
 akesh K. Jain. He is currently Assistant Professor of Radiation Oncology a
 t Harvard Medical School and the Massachusetts General Hospital as well as
  a Member of the Harvard-MIT Health Sciences and Technology Faculty. Dr. P
 adera is recognized as a leader in the field of intravital functional lymp
 hatic imaging\, particularly with respect to tumor growth\, lymphatic meta
 stasis and lymphatic vessel pumping. Since December 2015 he is Associate P
 rofessor of Radiation Oncology at Massachusetts General Hospital/Harvard M
 edical School in Boston\, MA (USA).
LOCATION:SV1717.1 http://map.epfl.ch/?room=sv1717.1
STATUS:CONFIRMED
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