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SUMMARY:Functional Relevance of Mitochondrial DNA Methylation
DTSTART:20160502T100000
DTEND:20160502T110000
DTSTAMP:20260513T015954Z
UID:2a02d5bac59264760547eb9beadfb5f6e6234629d760b55466e8ff08
CATEGORIES:Conferences - Seminars
DESCRIPTION:Monique van der Wijst\, University Medical Center\, Groningen 
 (NL)\nSEMINAR of the LAUSANNE INTEGRATIVE METABOLISM and NUTRITION ALLIANC
 E (LIMNA)Abstract:\nMitochondrial diseases can be the result of sequence m
 utations in mitochondrial (mtDNA) or nuclear DNA (nDNA). In addition to su
 ch DNA mutations\, epigenetic mutations affecting gene expression may also
  contribute to mitochondrial diseases. In this respect\, most research foc
 uses on epigenetic modifications of the nDNA. Alternatively\, the discover
 y of a mitochondria-targeted DNA methyltransferase 1 in 2011\, boosted the
  field of mitochondrial epigenetics. Since then\, a few dozen of papers re
 vealed the mitochondrial presence of other epigenetic enzymes\, CpG and no
 n-CpG methylation\, and their link with aging and disease\, among which ca
 ncer\, diabetes and Alzheimer’s disease. To reveal the functional contri
 bution of this epigenetic modification in the mtDNA\, we have targeted sev
 eral DNA methylating enzymes to the mtDNA. Subsequently\, the effect of mt
 DNA methylation on mitochondrial gene expression\, DNA replication and mit
 ochondrial function was determined. Unraveling the impact of epigenetic re
 gulation of the mtDNA will be essential in the understanding of and in int
 erfering with the role of mitochondria in many physiological and pathophys
 iological processes.Authorship:\nMonique GP van der Wijst (1)\, A Mposhi (
 1\, 2)\, AY van Tilburg (1)\, M G Rots (1)\n1. Epigenetic Editing\, Dept. 
 Pathology and Medical Biology\, University Medical Center Groningen\, Hanz
 eplein 1 9713 GZ Groningen\, The Netherlands\n2. Dept of Hepatology and Ga
 stroenterology\, University Medical Center Groningen\, Hanzeplein 1 9713 G
 Z Groningen\, The Netherlands.Bio:\n2007 – 2010:   Radboud Universitei
 t Nijmegen\, Bsc\, Biomedical Sciences\n2010 – 2012:   Vrije Universit
 eit Amsterdam\, Msc\, Oncology\nSept. 2012 – Present:   University Med
 ical Center Groningen\, Dept. Pathology & Medical Biology\, Epigenetic Edi
 ting group\, PhD student
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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