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SUMMARY:Evolution and Function of Protein Phosphorylation Networks
DTSTART:20160502T121500
DTSTAMP:20260429T185816Z
UID:965677f0a746b8a9b3bf3894f58c2d6148716cf80a3ae7239331295a
CATEGORIES:Conferences - Seminars
DESCRIPTION:Pedro Beltrao\, Ph.D.\, EMBL- EBI\, Hinxton\, Cambridgeshire (
 UK)\nBIOENGINEERING SEMINAR(sandwiches served)Abstract:\nCells need to con
 stantly adapt to changes in conditions and use different mechanisms to tra
 nsfer information from sensors to the effectors of cellular responses. One
  of the fastest mechanisms is the reversible post-translational modificati
 on of proteins such as protein phosphorylation. Advances in mass-spectrome
 try now allow us to identify phosphosites in large scale and quantify thei
 r changes across different conditions.  However\, little is known about h
 ow the thousands of recently discovered phosphosites evolve\, how they mod
 ulate protein function or how they act in coordinated fashion to dictate a
  cellular response.\nI will describe recent progress from our group in add
 ressing these issues. We are developing methods to infer the most likely a
 ge of phosphosites by combining phosphorylation data from multiple species
 \, protein sequences and phylogenetic trees. We have observed that only a 
 small fraction of phosphosites are ancient in origin and that these are mo
 re likely to cause deleterious consequences when mutated.\nIn parallel we 
 are analysing changes in phosphosite abundances under different conditions
 . We have compiled a dataset of 150 perturbations in human cell lines wher
 e we can estimate the activities of approximately 200 kinases. These data 
 allows to characterize cell signalling states across conditions and to inf
 er associations between kinase activities and the phosphorylation levels o
 f protein complexes.Bio:\nPhD in Biology\, University of Aveiro (research 
 conducted at EMBL-Heidelberg)\, 09/2007.\nPostdoctoral research at the Uni
 versity of California San Francisco.\nGroup leader at EMBL-EBI since 2013.
LOCATION:SV1717.1 http://map.epfl.ch/?room=sv1717.1
STATUS:CONFIRMED
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