BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:Interplay between Circadian and Redox Oscillations in Eukaryotes
DTSTART:20160609T110000
DTSTAMP:20260415T122032Z
UID:8421ca125a5fd36e19b1a754209a8363192269d9668c3938219d5375
CATEGORIES:Conferences - Seminars
DESCRIPTION:Guillaume Rey\, Ph.D.\, University of Cambridge\, Cambridge (U
 K)\nBIOENGINEERING SEMINARAbstract:\nThe circadian clock is a ubiquitous t
 imekeeping system that organizes the behaviour and physiology of organisms
  over the day and night. Current models rely on transcriptional networks t
 hat coordinate circadian gene expression of thousands of transcripts. Howe
 ver\, recent studies have uncovered phylogenetically conserved redox rhyth
 ms that can occur independently of transcriptional cycles. Here we identif
 y the pentose phosphate pathway (PPP)\, a critical source of the redox cof
 actor NADPH\, as an important regulator of redox and transcriptional oscil
 lations. Our results show that genetic and pharmacological inhibition of t
 he PPP prolongs the period of circadian rhythms in human cells\, mouse tis
 sues and in fruit flies. These metabolic manipulations also cause a remode
 lling of circadian gene expression programmes that involves the circadian 
 transcription factors BMAL1/CLOCK\, and the redox-sensitive histone acetyl
 transferase p300. Thus\, the PPP regulates circadian rhythms via NADPH met
 abolism\, suggesting a pivotal role for NADPH availability in circadian ti
 mekeeping.Bio:\nMar 2012–present     Research Associate\, Department
  of Clinical Biochemistry\, University of Cambridge\, Cambridge (UK)\nJul 
 2007–Sep 2011   PhD Student\, School of Life Sciences\, EPFL\, Lausann
 e (CH)
LOCATION:AI 1 153 http://map.epfl.ch/?room=ai1153
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR