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SUMMARY:Single-Molecule Analysis with Nanomechanical Systems
DTSTART:20160906T110000
DTEND:20160906T120000
DTSTAMP:20260505T041246Z
UID:86b0f42f258deb230a961161c1f72763e600c4795b68f52ed0f9c288
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Michael Roukes\, Caltech\nBio: Michael Roukes is the Rob
 ert M. Abbey Professor of Physics\, Applied Physics\, and Bioengineering a
 t the California Institute of Technology.  His scientific interests range
  from quantum measurement to applied biotechnology with a unifying theme o
 f the development\, very-large-scale integration and application of comple
 x nanosystems to precision measurements in physics\, the life sciences and
  medicine.  Roukes was the founding Director of Caltech's Kavli Nanoscien
 ce Institute (KNI) from 2003-2006.  In 2007\, he co-founded the Alliance 
 for Nanosystems VLSI (very-large-scale integration) with scientists and en
 gineers at CEA/LETI in Grenoble\, which maintains a $B-scale microelectron
 ics research foundry.  He then continued as co-director of Caltech’s KN
 I from 2008 until 2013. Since then he has returned to full-time pursuit of
  research efforts with his group and collaborators. Concurrent with his Ca
 ltech appointment\, he has held a Chaire d’Excellence in nanoscience in 
 Grenoble\, France since 2008.  Among his honors\, Roukes is a recipient o
 f the NIH Director’s Pioneer Award and has been awarded Chevalier (Knigh
 t) dans l'Ordre des Palmes Academiques by the Republic of France.\nNEMS (n
 anoelectromechanical systems) now enable ultrasensitive measurement of the
  inertial mass of individual atoms and molecules [1]. We have employed NEM
 S devices to realize a new form of mass spectrometry (MS) enabling single-
 molecule analysis\, and with it have analyzed individual large-mass biomol
 ecular complexes\, one-by-one\, in real-time [2]. Recently\, we developed 
 an approach that enhances our previously demonstrated capabilities of NEMS
 -MS by resolving the spatial mass distribution of the individual analytes 
 – in real time with molecular-scale resolution – upon their adsorption
  onto the NEMS sensor [3]. This new approach\, which we term inertial imag
 ing\, employs the ensemble of discrete time-correlated perturbations\, res
 ulting from each molecular adsorption event\, to yield the spatial moments
  of the mass distribution in real time for each analyte. The lowest moment
  yields the analyte’s total mass\; higher moments reveal its center-of-m
 ass position of adsorption\, the analyte’s average diameter\, and its sp
 atial skew and kurtosis\, etc. Once acquired\, these moments can be employ
 ed to reconstruct the analyte’s “inertial image”. Unlike conventiona
 l imaging\, the precision of inertial imaging is not set by wavelength-dep
 endent diffraction phenomena\; instead frequency fluctuation processes det
 ermine the ultimate limits of spatial resolution. Today’s advanced NEMS 
 devices are capable of resolving molecular-scale analytes. One of the most
  exciting current fields of application for this method focuses on the ana
 lysis of large proteins and biomolecular complexes – for example\, membr
 ane proteins\, antibody isoforms\, organelles\, and viruses – in their n
 ative (unfragmented and non-denatured) state.\n[1] Naik\, A. K.\, Hanay\, 
 M. S.\, Hiebert\, W. K.\, Feng\, X. L. & Roukes\, M. L.\, Towards Single-m
 olecule Nanomechanical Mass Spectrometry. Nature Nanotechnology 4\, 445–
 450 (2009).\n[2] Hanay\, M. S.\, Kelber\, S. I.\, Naik\, A. K.\, Chi\, D.\
 , Hentz\, S.\, Bullard\, E. C.\, Colinet\, E.\, Duraffoug\, L. & Roukes\, 
 M. L.\, Single-protein Nanomechanical Mass Spectrometry in Real Time. Natu
 re Nanotechnology\, 7\, 602-608 (2012).\n[3] Hanay\, M. S.\, Kelber\, S. I
 .\, O'Connell\, C. D.\, Mulvaney\, P.\, Sader\, J. E. & Roukes\, M. L.\, I
 nertial Imaging with Nanomechanical Systems. Nature Nanotechnology 10\, 33
 9-344 (2015).
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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