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SUMMARY:Dissecting cancer metastasis through the analysis  of circulating 
 tumor cells
DTSTART:20160613T110000
DTSTAMP:20260510T235209Z
UID:6259d1943a9b356a79e95729f446eee0f58274d60a9bf65a7e79af0d
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Nicola Aceto\, University of Basel\nProf. Aceto's group is
  interested in understanding the molecular mechanisms that drive the devel
 opment and maintenance of cancer metastasis\, with a particular focus on t
 he analysis of circulating tumor cells. In our studies\, we use a combinat
 ion of microfluidics technologies\, patient samples\, in vivo models\, nex
 t-generation sequencing\, molecular and computational biology to study how
  cancer spreads. We strive to identify metastasis-specific therapeutic tar
 gets to enable the development of new therapies that will suppress this di
 sease.\nThey recently reported that CTC-clusters\, i.e. cancer cell aggreg
 ates in circulation held together by interepithelial cell-cell junctions\,
  are precursors of breast cancer metastasis (Aceto et al.\, Cell\, 2014) .
  They have developed a new microfluidics device with specialized bifurcati
 ng traps to isolate CTCs from patients with metastatic breast or prostate 
 cancer or melanoma (Sarioglu and Aceto et al.\, Nature Methods\, 2014).
LOCATION:SV 1717.1 http://plan.epfl.ch/?request_locale=fr&room=sv1717
STATUS:CONFIRMED
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