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SUMMARY:New Catalysts\, Methods\, and Strategies that Enable Therapeutic D
 evelopment and On-Demand Natural Product Total Synthesis
DTSTART:20160906T171500
DTEND:20160906T183000
DTSTAMP:20261005T021955Z
UID:321552538b48a846c3433a5be8c0359570b179d3e1ee6bfdc0ef245a
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Jeffrey N. Johnston\, Vanderbilt University\, USA\nSmall
  molecules are a mainstay of drug development\, offering structural and fu
 nctional topologies to precisely occupy receptor pockets. Increasingly com
 plex protein-protein interactions demand greater breadth of structural and
  stereochemical complexity\, as well as size\, within a discrete compound 
 collection. Furthermore\, the incorporation of fluorine into small molecul
 es can provide directed conformational bias\, enhance desirable drug like 
 properties\, and improve metabolic stability. All of these features are me
 aningful only when they are at arm’s reach – essentially on-demand –
  such that attention is focused predominantly on greater issues of potency
  and selectivity. Tools that enhance the immediacy of availability and acq
 uisition are in high demand.\nWe have combined new catalyst development wi
 th new reaction development to provide unfettered access to a broad range 
 of chiral nonracemic amines\, diamines\, amino acids\, and diverse heteroc
 ycles. Our latest work in this area will be described\, with an emphasis o
 n the stereocontrolled formation of carbon-heteroatom bonds (C-O\, C-N\, C
 -F)\, unnatural amino acid-containing peptides\, and depsipeptides with ma
 crocycles up to 60-atoms in size.
LOCATION:BCH 2118
STATUS:CONFIRMED
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