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SUMMARY:How Do Enzymes Really Work and How Do They Not Work: What Has Been
  Learnt From Computer Simulation Studies? 
DTSTART:20090519T110000
DTSTAMP:20260510T084007Z
UID:668f999aced08d0e6b1afb2ec100079cbbeeeb1b6d8768e9ada983bc
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Arieh Warshel\, University of Southern California\nBiolo
 gical systems were optimized by evolution to reach a maximum overall effic
 iency. However\, the available structural\, spectroscopical\, and biochemi
 cal information does not allow one to determine what the most important ca
 talytic contributions are. Apparently\, in many cases it is crucial to use
  computer simulation approaches in order to find out the actual contributi
 on from the different proposed catalytic factors (1-3). The talk will star
 t with a clear definition of catalysis\, emphasizing the crucial need for 
 a reference state. After a brief description of reliable approaches for th
 e simulation of enzymatic reactions\, we will point out that all consisten
 t simulation studies have concluded that enzymes work by using their preor
 ganized polar environment to stabilize the transition state of the reactin
 g substrates. [...]
LOCATION:BCH 3118 https://plan.epfl.ch/?room==BCH%203118
STATUS:CONFIRMED
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