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SUMMARY:Immuno-engineered Organoids and Nanogels for Modulating the Fate o
 f Healthy and Diseased Immune Cells
DTSTART:20160912T121500
DTSTAMP:20260510T235156Z
UID:f4ba90fd1721879a974b9768afaa6ddf36a753b1ba51f1edf7411c99
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Ankur Singh\, Cornell University\, Ithaca\, NY (USA)\nBI
 OENGINEERING SEMINAR\n(sandwiches served)\n\nAbstract:\nEx vivo immune org
 ans can enable mechanistic understanding of the immune system\, provide a 
 deeper understanding of the mechanisms that lead a variety of immune-relat
 ed malignancies\, including B and T cell lymphomas\, and more importantly\
 , accelerate the translation of immunotherapies. In this talk\, I will dis
 cuss two complementary strategies developed in my lab which recapitulates 
 the anatomical microenvironment of a lymphoid tissue and provides the basi
 s to regulate the kinetics of immune reaction as well as mimic a neoplasm-
 like heterogeneous microenvironment. These strategies could\, in the long 
 term\, change the understanding of the initiation and progression of hemat
 ological tumors\, allow primary bio-specimen analysis\, provide prognostic
  values\, and importantly\, allow a faster and more rational screening and
  translation of therapeutic regimens. Finally\, I will talk about the role
  of mechanical forces found in lymphoid tissues on lymphomas and nano-engi
 neered approaches towards safer cancer immunotherapy. Soluble antigen-base
 d cancer vaccines have poor retention in tissues along with suboptimal ant
 igen processing by dendritic cells. Multiple booster doses are often neede
 d\, leading to dose-limiting systemic toxicity. A versatile\, immunomodula
 tory\, self-assembly protein nanogel vaccine will be described that induce
 s robust immune cell response at lower antigen doses than soluble antigens
 \, an important step towards biomaterials-based safer immunotherapy approa
 ches. These examples illustrate the power of bioengineering approaches in 
 shaping the immune response and studying immune cell biology.\n\nBio:\ncur
 rent:   Assistant Professor\, Mechanical Engineering\, Cornell Universit
 y\, Ithaca\, NY \n2010-13: Post-Doctoral Fellow\, Mechanical Engineering\
 , Georgia Institute of Technology\n2006-10: Ph.D. Biomedical Engineering\,
  The University of Texas at Austin\n2004-06: M.Tech. Biomedical Engineerin
 g\, Indian Institute of Technology-Bombay
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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