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SUMMARY:TOR signaling and the control of cell growth
DTSTART:20090612T153000
DTSTAMP:20260924T155232Z
UID:9442eb9cc5e3d8d1abeb32a80a8b1c04ad9cbdb4e329163122c47014
CATEGORIES:Conferences - Seminars
DESCRIPTION:Michael N. Hall\nTOR (target of rapamycin) is a highly conserv
 ed serine/threonine kinase that controls cell growth and metabolism in res
 ponse to nutrients\, growth factors\, cellular energy\, and stress. TOR wa
 s originally discovered in yeast but is conserved in all eukaryotes includ
 ing plants\, worms\, flies\, and mammals. The discovery of TOR led to a fu
 ndamental change in how one thinks of cell growth. It is not a spontaneous
  process that just happens when building blocks (nutrients) are available\
 , but rather a highly regulated\, plastic process controlled by TOR-depend
 ent signaling pathways. TOR is found in two structurally and functionally 
 distinct multiprotein complexes\, TORC1 and TORC2. The two TOR complexes\,
  like TOR itself\, are highly conserved. Thus\, the two TOR complexes cons
 titute an ancestral signaling network conserved throughout eukaryotic evol
 ution to control the fundamental process of cell growth. As a central cont
 roller of cell growth\, TOR plays a key role in development and aging. The
  physiological consequences of mTORC1 dysregulation suggest that inhibitor
 s of mTOR may be useful in the treatment of age-related diseases such as c
 ancer\, cardiovascular disease\, and metabolic disorders.\nWhile the role 
 of TOR in controlling growth of single cells is relatively well understood
 \, the challenge now is to understand the role of TOR signaling in coordin
 ating and integrating overall body growth (and aging) in multicellular org
 anisms. This will require elucidating the role of TOR signaling in individ
 ual tissues. Data on the role of mTORC1 and mTORC2 in specific tissues wil
 l be presented.
LOCATION:SV 1717A
STATUS:CONFIRMED
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