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SUMMARY:Low-cost analytical device for counterfeits detection in emerging 
 countries
DTSTART:20161103T110000
DTEND:20161103T120000
DTSTAMP:20260510T105752Z
UID:b5a64538e6502057e45785c0718cf220cefdc7e0ed7b2d47633d40b1
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Rudaz Serge\nHead of Biomedical and Metabolomic Analysis
  group\, School of Pharmaceutical Sciences\, University of Geneva\, Switze
 rland\nThe proportion of counterfeit medicines has dramatically increased 
 in the last few years. According to numerous official sources\, the propor
 tion has reached 80% in African countries. The fight against this calamity
  is complex and different levels of action are necessary. Among them\, the
  quality control of batches imported into the different countries can be a
 chieved\, although this strategy is often difficult to apply due to a lack
  of suitable analytical equipment in developing countries.\n\nSimple\, rel
 iable\, and cost-efficient drug control approaches are needed and the curr
 ently used methods entail numerous drawbacks such as\n(i) the availability
  of reference substances\,\n(ii) the maintenance of analytical instruments
 \, and\n(iii) the availability and costs of consumables.\n\nIn this contex
 t\, the use of capillary electrophoresis (CE) appears of utmost interest s
 ince the separation is achieved in a capillary of reduced dimension (total
  volume of 1 uL)\, filled with an aqueous buffered solution of electrolyte
 s. No organic solvent is needed and injection volumes are in the nanoliter
  range\, which is perfectly adapted to the low availability of reference s
 ubstances. Another CE feature is the equipment simplicity\, with no mechan
 ical constraint and simplified maintenance\, only requiring a periodical c
 ontrol of the electrodes and detection performance during routine analyses
 \n\nThe low-cost CE was successfully implemented in 8 emerging countries (
 i.e. Mali\, Cambodia\, Senegal\, Republic of Congo\, Rwanda\, Burkina Faso
 \, Tanzania and Madagascar) leading to several missions\, conventions (e.g
 . Pharmelp\, Pharmaciens sans Frontières) scientific communications (5 ar
 ticles\, 4 oral communications\, 5 posters)\, dissemination (>50 press rel
 eases and interviews)\, and international recognitions (e.g. runner up for
  the Humanity in Science Award from the Analytical Scientist in 2015). In 
 order to analyze a high number of compounds and benefit from the device wi
 th the basic chemistry knowledge\, we developed simple and generic methods
 \, which were validated according to regulatory guidelines and are current
 ly applied for the simultaneous qualitative and quantitative analysis of m
 ore than 80 drugs from the list of the 200 essential medicines defined by 
 the World Health Organisation.\n\nAccording to the feedback gathered throu
 gh the missions regarding the instrument\, the methods\, and the field con
 straints\, a new generation of device is currently under development in co
 llaboration with Prof. H. Girault (EPFL\, Sion) and his team. The further 
 steps of the project should include:\n(i)     a new/renewable energy s
 ource to supply HV regardless of the local electric facilities\n(ii)   
  a new detection system to broaden the analysis range to any pharmaceutica
 l drug\n(iv)   an integrated SW to simplify data treatment and reporting
 \n\nThe seminar can also be followed either from an equipped room with vis
 io-connection in EPFL Lausanne or with a computer with Jabberguest using t
 he link https://jabberguest.epfl.ch/call/58300. Please connect at least 15
 -20 minutes in advance. Past this period\, the connection won't be accepte
 d anymore.
LOCATION:Zeuzier https://www.google.com/maps/place/EPFL+Valais+Wallis/?ref
 =zeuzier
STATUS:CONFIRMED
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