BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:BMI Seminar // Of flies and mice: insights on molecular mechanisms
  of Autism
DTSTART:20170201T121500
DTEND:20170201T131500
DTSTAMP:20260916T044027Z
UID:2e09c0e12c8f1abb5eb5734f12cdbbea0bc7ebe73f85b0d0b7ab995a
CATEGORIES:Conferences - Seminars
DESCRIPTION:Claudia Bagni\,\n\nDepartment of Fundamental Neuroscience\, Fa
 culty of Biology and Medicine\, University of Lausanne\, Switzerland\n\n&\
 n\nDepartment of Biomedicine and Prevention\, Faculty of Medicine\, Univer
 sity of Rome Tor Vergata\, Italy\nOne fourth of the population is estimate
 d to be affected by a mental or behavioural disorder\, including schizophr
 enia (SCZ)\, autism spectrum disorder (ASD) and intellectual disability (I
 D). These pathologies are typically associated with disturbed early neurod
 evelopment. CYFIP1 (Cytoplasmic FMRP Interacting Protein 1) is a strong ca
 ndidate gene for several mental disorders. In humans the CYFIP1 gene is lo
 cated on chromosome 15q11.2\, a highly unstable region associated to ASD\,
  SCZ and Epilepsy. In addition\, CYFIP1 has two important functions: (1) i
 t binds the RNA-binding protein Fragile X Mental Retardation Protein (FMRP
 ) and (2) is part of the WAVE regulatory complex involved in actin dynamic
 s. Therefore\, CYFIP1 regulates local protein synthesis and actin remodeli
 ng\, two key processes important for proper synaptic function and developm
 ent. During my lecture I will discuss how using mouse and fly models as we
 ll patients’ cells\, we identified CYFIP1-mediated mechanisms involved i
 n neuronal development and social behaviour. We propose that CYFIP1 may b
 e a hub for different neurological and intellectual disability disorders.
  \n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR