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SUMMARY:BMI Seminar // Insulin signaling and compulsivity: a translational
  perspective
DTSTART:20170301T121500
DTEND:20170301T131500
DTSTAMP:20260916T062941Z
UID:e44f81ba8b70ddc32644497fd35a3586106d65281c93bfe82837b2b8
CATEGORIES:Conferences - Seminars
DESCRIPTION:Jeffrey Glennon\, Dept. of Cognitive Neuroscience\, Donders In
 stitute\, Radboud University Medical Center\, Nijmegen\, Netherlands\n\n 
 \nObsessive compulsive disorder (OCD) is characterized by compulsive beha
 vior punctuated by anxiety-driven obsessive episodes. A genetic network 
 based approach was utilized to construct a genetic landscape of human OC
 D related targets based on pathway (IPA\; WebGestalt) and gene ontology 
 analysis of 2 genome wide association studies (GWAS) of OCD which highlig
 hted the role of 66 candidate genes. Of these\, several were associated 
 with insulin signaling including IGF1 and KCNQ1. Furthermore\, expression
  of microRNA associated with insulin signaling (miRs 128\, 129\, 221 and 
 455) were increased in a rat OCD model of compulsive lever pressing (sig
 nal attenuation). Increased insulin resistance may be key to compulsive 
 behavior\, as impaired spontaneous alternation\, reversal learning and e
 xtinction were observed in a Type II diabetes animal model (the TALLYHO m
 ice) which were correlated with decreased cerebellar IGF1 protein levels
 . No effect was seen in a Type I diabetes model (Alloxan treated mice). 
 Finally\, a current front-line type II diabetes medication (which decrea
 ses insulin resistance) metformin in pilot studies demonstrates a marked 
 reduction in quinpirole-induced compulsive checking in rats. Proxy geneti
 c\, microRNA and MRI-DTI structural connectivity markers are currently u
 nder investigation.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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