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SUMMARY:Chromatin Structure Shapes the Search Process of Transcription Fac
 tors
DTSTART:20160819T121500
DTSTAMP:20260610T235629Z
UID:094ed3e52f81156b11a6cc907ca490b525bf021a6486dfeb87d4d8b9
CATEGORIES:Conferences - Seminars
DESCRIPTION:Nacho Molina\, Ph.D.\, IGBMC Strasbourg\, Illkirch (F)\nBIOENG
 INEERING SEMINARAbstract:\nThe diffusion of regulatory proteins within the
  nucleus plays a crucial role in the dynamics of transcriptional regulatio
 n. The standard kinetic model assumes a 3D plus 1D diffusion process: regu
 latory proteins either move freely in solution or slide on linear DNA. How
 ever recent single molecule experiments have suggested that 3D structure o
 f chromatin may influence the diffusion process.\nIn this talk\, I will pr
 esent a novel stochastic diffusion model that integrates high-resolution i
 nformation on the 3D structure of chromatin with DNA-protein interactions.
  Thus\, the dynamics of transcription factors (TFs) is modelled as a slide
  plus jump diffusion process on a chromatin network constructed from high-
 resolution Hi-C data.\nOur model allows to uncover the effects of chromati
 n structure on the diffusion process and provides genome-wide testable pre
 dictions for the occupancy profiles of TFs and target search times. Furthe
 rmore\, we showed that binding sites clustered on a small number of topolo
 gical associated domains leading to a higher local concentration of TFs. T
 his could reflect an optimal strategy to efficiently use limited transcrip
 tional resources.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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