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PRODID:-//Memento EPFL//
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SUMMARY:Regulation of DUOX and IMD pathway in Drosophila gut immunity
DTSTART:20090529T153000
DTSTAMP:20260919T215348Z
UID:b5f86bd6e4686152a76dda2ac56449b10db201848843c8f7770e3648
CATEGORIES:Conferences - Seminars
DESCRIPTION:Won-Jae Lee\nOne of the fundamental questions relevant to all 
 metazoans is how gut immunity manages different microbes. At present\, hos
 t factors required to maintain healthy gut-microbe homeostasis are largely
  unknown. Here\, we show that the intestinal homeobox gene Caudal (Cad) is
  indispensable for immune homeostasis in preserving the indigenous commens
 al community and host health. In a commensal-rich gut environment where th
 e NF-kB activation is constitutive albeit at a low level\, Cad maintains t
 he minimum antimicrobial potential by repressing NF-kB-dependent antimicro
 bial peptide (AMP) genes. Our in vivo experiments showed that Cad is an es
 sential determinant that regulates a delicate immune homeostasis for healt
 hy commensal-gut interaction.\nIn the case of pathogen-gut interactions\, 
 however\, host mounts a robust innate immunity based on reactive oxygen sp
 ecies (ROS) through dual oxiase (DUOX). DUOX is subjected to multiple regu
 lations to adjust immune intensity depending on the nature of gut-microbe 
 interactions. Multiple regulations of DUOX and their in vivo values will a
 lso be discussed.\nThese results reveal that multiple regulations of signa
 ling leading to ROS and AMP generation within a host enable the protection
  of beneficial flora as well as efficient elimination of transient microbe
 s\, which ultimately influences host physiology.
LOCATION:SV 1717A
STATUS:CONFIRMED
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