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SUMMARY:Synthetic Mammalian Gene Networks
DTSTART:20090528T121500
DTSTAMP:20261005T064924Z
UID:224643d77e7791bfa1f6ba75ed267f4233f6783a856b0aaa7c6ce5bb
CATEGORIES:Conferences - Seminars
DESCRIPTION:Martin Fussenegger\nCapitalizing on our latest advances in the
  design of heterologous mammalian transgene control systems we have engine
 ered a variety of gene expression circuitries with unique signal processin
 g capacities in mammalian cells and mice. Some of our highlights include: 
 (i) (semi-) synthetic regulatory cascades\, which process physiologic and 
 synthetic signals into up to six discrete expression levels\; (ii) epigene
 tic toggle switches that lock transgene expression at high and low levels 
 for several weeks in response to transient administration of inducer molec
 ules\; and (iii) hysteretic expression networks\, which can buffer small c
 hanges in inducer molecule concentration. The latest-generation synthetic 
 mammalian gene networks provide circadian clock-like oscillating transgene
  expression or emulate synthetic ecosystems which reveal unique cross-talk
  dynamics between species sharing the same habitat. One such cross-talk ci
 rcuit coordinates the metabolic communication between mammalian cells and 
 Mycobacterium tuberculosis and has been used successfully to screen for co
 mpounds that knock down the ethionamide-resistance pathway of this pathoge
 n\, making it resusceptible to this antibiotic. We believe that the design
  of synthetic gene networks\, which process molecular signals with near di
 gital precision\, may provide novel therapeutic opportunities.
LOCATION:SV 1717A
STATUS:CONFIRMED
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