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SUMMARY:Monitoring and modulating tuberculosis in the transparent zebrafis
 h
DTSTART:20090424T153000
DTSTAMP:20260408T121037Z
UID:158d732e209334134236ab45ed1f89e1648b4eb5e095057d54231da5
CATEGORIES:Conferences - Seminars
DESCRIPTION:Lalita Ramakrishnan\nThe transparent zebrafish has emerged as 
 a powerful model system to study the early events of tuberculosis. This sy
 stem offers two major advantages: optical clarity and genetic tractability
 . We use real-time microscopy to visualize the sequential stages of the ho
 st-bacterium interaction in experimentally infected animals. We modulate t
 hese stages by creating defined mutations in both the host and the pathoge
 n\, and we determine how these stages contribute to infection outcomes. Ou
 r studies have provided some surprising new insights into the role of the 
 tuberculous granuloma\, the hallmark tissue structure of tuberculosis\, in
  the expansion and dissemination of infection within the host.
LOCATION:SV 1717A
STATUS:CONFIRMED
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