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SUMMARY:From gene-finding to understanding disease risk in neurodevelopmen
 tal psychiatric disorders
DTSTART:20170324T110000
DTEND:20170324T120000
DTSTAMP:20260510T215953Z
UID:99ababa41f87c137f41e84041803534fd5add38a45f0773672ae451a
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Barbara Franke\nFrom gene-finding to understanding disease
  risk in neurodevelopmental psychiatric disorders\nProf. Dr. Barbara Frank
 e\, Donders Institute for Brain\, Cognition and Behaviour\, Radboud Univer
 sity Medical Center\, Nijmegen\, The Netherlands\nThese are great times in
  psychiatric genetics! Through international collaboration and technologic
 al progress we are finally starting to identify the genes for psychiatric 
 disorders. Using genome-wide association and next generation sequencing\, 
 we end up with genes and genetic variants\, that are statistically correla
 ted with disease. In the first part of the presentation\, I will show rece
 nt findings for attention-deficit/hyperactivity disorder (ADHD)\, which is
  the particular focus of the research in my lab.\nHow can we go from the s
 tatistical definition of a link between gene and disease to a more biologi
 cal understanding of the involvement of a gene and its variants? And how c
 an we make such findings useful for the patient? In the second part of my 
 presentation\, I will discuss different approaches that we employ at diffe
 rent levels of organismal complexity. These include neuroimaging genetics 
 research - linking genetics\, brain\, and behavior\,  bioinformatics appr
 oaches that may clarify the biochemical processes affected and enable lead
  identification for treatment innovation\, and work in cell and animal mod
 els. For the latter\, my group has recently pioneered the use of Drosophil
 a melanogaster\, the fruit fly\, as a cheap and versatile small animal mod
 el for ADHD. I will show our first results using induced neuron models. Bo
 th of those can help us to move beyond correlation to causality for specif
 ic genes and variants. While every individual step of this research can im
 prove our understanding of the disorder individually\, solving the puzzle 
 of ADHD etiology and improving treatment will require integration of resea
 rch across levels and disciplines.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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