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SUMMARY:Enriching sensory regeneration after spinal injury by neuronal act
 ivity-dependent epigenetic reprogramming
DTSTART:20161004T150000
DTEND:20161004T160000
DTSTAMP:20260430T014816Z
UID:9283a20bb0bcffc8b61635385f975042c738d65b1ed7288fc420c143
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Dr. Simone DI GIOVANNI\nInjury to the adult mammalian ne
 rvous system leads to permanent deficits in sensory and motor function. Th
 is is partly due to the inability of neurons to initiate an effective mole
 cular regenerative response\, resulting in failed axon regeneration. Senso
 ry neurons in the dorsal root ganglia (DRG) are vital for physiological an
 d post-injury sensorimotor function as they receive and convey sensory inf
 ormation from the environment to motor circuits in the spinal cord and bra
 in. Here we show that exposing mice to environmental enrichment (EE) prior
  to an injury induces a long-lasting increase in the regenerative potentia
 l of DRG neurons.  Moreover\, prior exposure to EE augmented sensory axon
  regeneration and functional improvements after spinal cord injury\, which
  was further enhanced when combined with a conditioning injury. Specifical
 ly\, EE stimulated an increase in sensory axon regeneration by enhancing n
 euronal activity and calcium signalling\, leading to increased axonal tran
 sport and CBP-dependent histone acetylation\, which were required to repro
 gram the DRG neurons for regeneration. Importantly\, the use of a small mo
 lecule based CBP activator promotes recovery after spinal cord injury by p
 romoting axonal regeneration of sensory and motor fibers.  Overall this w
 ork portrays EE as a physiological means of priming sensory neurons for fu
 nctionally relevant axon regeneration after injury\, which is elicited thr
 ough increased neuronal activity leading to enduring epigenetic reprogramm
 ing. Lastly\, it suggests a novel translational opportunity for clinical S
 CI with the use of a small molecule based CBP activator\, which promotes r
 ecovery after experimental SCI.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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