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SUMMARY:Counting Stem Cells in the Drosophila Intestine: “You Can Go Hom
 e Again”
DTSTART:20161010T120000
DTEND:20161010T130000
DTSTAMP:20260427T223648Z
UID:0e9fb671fc8e0203a6189856e0e927fa8dd1cba9f9887d0c9917a8a9
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Benjamin Ohlstein\, Columbia University Medical Center\,
  New York\, US\nDrosophila intestinal stem cells (ISCs) generate enterocyt
 es (ECs) and enteroendocrine (ee) cells. Previous work suggests that diffe
 rent levels of the Notch ligand Delta (Dl) in ISCs unidirectionally activa
 te Notch in daughters to control multipotency. However\, the mechanisms dr
 iving different outcomes remain unknown. We found that during ee cell form
 ation\, the ee cell marker Prospero localizes to the basal side of dividin
 g ISCs. After asymmetric division\, the ee daughter cell acts as a source 
 of Dl that induces low Notch activity in the ISC to maintain identity. Alt
 ernatively\, ISCs expressing Dl induce high Notch activity in daughter cel
 ls to promote EC formation. Our data reveal a conserved role for Notch in 
 Drosophila and mammalian ISC maintenance and suggest that bidirectional No
 tch signaling may regulate multipotency in other systems.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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