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VERSION:2.0
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SUMMARY:Adult Stem Cell Control: from Lineage Decisions to Genome Stabilit
 y
DTSTART:20160923T121500
DTSTAMP:20260501T202425Z
UID:866fb2788c40a1c5e8eaf6a5f7596d01d6fb0b7dc7d9ea18ddf43722
CATEGORIES:Conferences - Seminars
DESCRIPTION:Allison Bardin\, Ph.D.\, Institut Curie\, CNRS\, Paris (F)\nBI
 OENGINEERING SEMINAR\n\nAbstract:\nAdult stem cells are long-lived residen
 ts in adult tissues acting to replenish terminally differentiated cells. 
  My seminar will explore two important questions of adult stem cell biolog
 y using the Drosophila intestinal stem cell model system: how are terminal
  cell fate decisions controlled and how stable is the genome of adult stem
  cells?  I will present evidence that secretory cell fate specification r
 equires Numb to inhibit Notch activity and I will discuss mechanisms upstr
 eam and downstream allowing EE cell fate specification.\n\nIn a second par
 t\, I will present our finding of frequent spontaneous mutations in adult 
 intestinal stem cells and their effects on the adult tissue.\n\nBio:\nEduc
 ation:\n2003: Ph.D.\, Biology\, Massachusetts Institute of Technology\, MA
  (USA)                          \n1997: B.A.\, Bi
 ochemistry\, University of California\, Berkeley\, CA (USA)\n\nResearch Ex
 perience:\nSeptember 2010-present:\n\nGroup Leader of Stem Cell and Tissue
  Homeostasis team in the Department of Developmental Biology and Cancer.\n
 Institut Curie (CNRS UMR 3215/ Inserm U934) CR1 CNRS\, Paris (F)\nInvestig
 ating novel mechanisms regulating adult stem cells using the Drosophila ad
 ult intestine.\n\n2006-August 2010:\nResearch scientist CR2 CNRS in the la
 b of Dr. Francois Schweisguth.\nInstitut Pasteur\, CNRS URA 2578 (Ecole No
 rmale Superieure\, CNRS UMR 8542 until 2008).\nInvestigating mechanisms co
 ntrolling the fate and differentiation potential of adult stem cell in the
  Drosophila intestine.\n\n2003-2005:\nPost-doctoral research fellow in the
  laboratory of Dr. François Schweisguth.\nEcole Normale Supérieure CNRS 
 UMR 8542\, Paris.\nControl of Notch signaling by ligand endocytosis in Dro
 sophila.\n\n1999-2003:\nPh.D. student in the laboratory of Pr. Angelika Am
 on\, Center for Cancer Research\, Massachusetts Institute of Technology\, 
 USA.\nStudied mitotic exit of the cell cycle in budding yeast.\n
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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