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SUMMARY:Symmetry Breaking and Self-Organisation in Mouse Development
DTSTART:20161006T101500
DTSTAMP:20260527T194542Z
UID:7f43c7baad68a65a07fd6b7e3e4da5076331b79dbcd016070cff3fc0
CATEGORIES:Conferences - Seminars
DESCRIPTION:Takashi Hiiragi\, M.D.\, Ph.D.\, European Molecular Biology La
 boratory (EMBL)\, Heidelberg (D)\nBIOENGINEERING SEMINAR\n\nAbstract:\nA f
 undamental question in biology is the mechanism by which the embryonic pol
 arity is established during development. Unlike many organisms\, mammalian
  eggs lack polarity and symmetry among cells has to be broken during early
  embryogenesis. This symmetry breaking results in formation of the blastoc
 yst\, consisting of two major cell types\, the inner cell mass and trophec
 toderm\, which are distinct in their position and gene expression. Recent 
 studies unexpectedly revealed that morphogenesis and gene expression is hi
 ghly dynamic and stochastic during this process. What signal breaks the in
 itial symmetry and how stochastic gene expression leads to the reproducibl
 y patterned blastocyst remain open questions about the beginning of mammal
 ian life. We have developed an experimental system to monitor early mouse 
 embryogenesis by live-imaging at unprecedented spatio-temporal resolution.
  This provides us with a basis for investigating the cellular and molecula
 r mechanism of symmetry breaking and self-organisation in early mammalian 
 development.\n\nBio:\nMDPhD 2000\, Kyoto University\, Japan.\nPostdoctoral
  research at the Max Planck Institute of Immunobiology\, Freiburg\, German
 y.\nGroup leader at the MPI of Immunobiology 2002-2007.\nIndependent group
  leader at the MPI for Molecular Biomedicine\, Münster\, 2007-2011.\nGrou
 p leader at EMBL since 2011.\nERC Investigator.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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