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PRODID:-//Memento EPFL//
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SUMMARY:Access to an intracellular life style : the Apicomplexa way
DTSTART:20090507T121500
DTSTAMP:20261004T230910Z
UID:6a4ab5103ab32dea4c9485bf794ac321b7e22421b4dd78607bfd6a42
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dominique Soldati-Favre\nThe phylum of Apicomplexa represents 
 of a large group of obligate intracellular parasites responsible for sever
 e disease in humans and animals including malaria and toxoplasmosis. Glidi
 ng motility is an essential and fascinating apicomplexan-typical adaptatio
 n to their intracellular lifestyle. Members of this phylum rely on gliding
  motility for their migration across biological barriers and for host cell
  invasion and egress. This unusual substrate-dependent mode of locomotion 
 involves the concerted action of secretory adhesins\, a myosin motor\, fac
 tors regulating actin dynamics and proteases. During invasion\, complexes 
 of soluble and transmembrane proteins are discharged to the apical pole of
  the parasite\, some of them act as adhesins binding to host cell receptor
 s whereas others are involved in the moving junction formation. These comp
 lexes redistribute towards the posterior pole of the parasite via a physic
 al connection to the parasite actomyosin system and are eventually release
 d from the parasite surface by the action of parasite proteases. The acces
 s to host cell culminates by the sealing of a non-fusiongenic parasitophor
 ous vacuole inside which the parasite replicate safely.
LOCATION:SV 1717a
STATUS:CONFIRMED
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