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SUMMARY:Regulation of cullin–RING ubiquitin ligases: the adaptive exchan
 ge hypothesis
DTSTART:20161110T161500
DTEND:20161110T173000
DTSTAMP:20260916T044016Z
UID:784ff4490902bc356578d31df64792f4a72ab6ac6eb83fb58cd43197
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Ray Deshaies\, Caltech\, USA\nCullin–RING ubiquitin li
 gases (CRLs)  comprise a family of hundreds of enzymes that regulate many
  aspects of eukaryotic biology ranging from circadian rhythms to glutamine
  synthesis. Mutations in specific CRLs predispose to leukemia\, kidney\, a
 nd colon cancers\, among other diseases. In addition\, one particular CRL 
 is the key target of drugs commonly used to treat multiple myeloma. Given 
 their broad impact on biology\, we have been interested in understanding h
 ow these enzymes work and how they are regulated. In my talk I will focus 
 on regulation of these enzymes by dynamic cycles of assembly and disassemb
 ly. Each subfamily of CRLs comprises a common cullin–RING core shared by
  a group of substrate receptors. For the SCF subfamily of CRLs\, the subst
 rate receptors are F-box proteins. The human genome encodes ~70 different 
 F-box proteins. I will describe the ‘Adaptive Exchange’ hypothesis\, w
 hich posits that the assembly of F-box proteins into SCF complexes is regu
 lated by the presence of their cognate substrates\, such that the populati
 on of SCF complexes that exists at a given time in a cell is a reflection 
 of the substrates being generated in that cell. This hypothesis has import
 ant implications for remodeling of the ‘CRLome’ in response to environ
 mental and developmental signals\, and for evolution of the family of CRL 
 enzymes
LOCATION:SV1717.A http://plan.epfl.ch/?room=SV%201717
STATUS:CONFIRMED
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