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SUMMARY:BMI Seminar // The power to sense and signal: Mitochondrial regula
 tion of stress responses
DTSTART:20170426T121500
DTEND:20170426T131500
DTSTAMP:20260916T044011Z
UID:bf86361d1df8bf682870a793010b5cccbdf9134d6f6671b09bf4dfbb
CATEGORIES:Conferences - Seminars
DESCRIPTION:Martin Picard\, Dept of Psychiatry and Neurology\, Division of
  Behavioral Medicine\, Columbia Translational Neuroscience Initiative\, Co
 lumbia University\, New York\, USA\nIn addition to producing energy\, mito
 chondria perform a number of biochemical and signaling functions.  Recent
  evidence suggests that\, like neurons in neural networks\, mitochondria s
 ense\, integrate\, and signal. Mitochondria thereby transmit information a
 bout external stressors and translate it into molecular and physiological 
 responses.  To understand how this influences gene expression and multisy
 stemic neuroendocrine responses to psychological stress\, we genetically m
 anipulated different mitochondrial functions in cells and mice.  This wor
 k shows that mitochondria regulate the nature and magnitude of cellular an
 d systemic stress responses.  Additional studies in tissues of patients w
 ith mitochondrial DNA diseases reveal the existence of both novel mitochon
 drial structures and abnormal sub-cellular behavior in response to genetic
  stress.  Together\, these studies provide converging evidence for a here
 tofore unsuspected role of mitochondrial signaling from organelle to organ
 ism.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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