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SUMMARY:Sleep homeostasis and circadian rhythms: a molecular perspective
DTSTART:20090402T121500
DTSTAMP:20260916T082113Z
UID:7cc656230088604cb72ac3c7fde5716b68c317b6796ee20f0b1c53f0
CATEGORIES:Conferences - Seminars
DESCRIPTION:Paul Franken\nIn the study of sleep two main regulatory proces
 ses have to be considered: a homeostatic process that is activated by and 
 counters the effects of sleep loss and a circadian process that determines
  the time–of–day sleep preferably occurs. The fine–tuned interaction
  between the two permits us to stay awake and alert throughout the day and
  to remain asleep at night. To gain inside into the molecular correlates o
 f the homeostatic process and its interaction with the circadian process w
 e apply a combination of forward\, molecular\, and reverse genetic approac
 hes in the mouse. Using Quantitative Trait Loci (QTL) analysis in recombin
 ant inbred (RI) lines of mice as a forward genetics tool\, we identified t
 he Dps1 QTL for the homeostatic sleep response after sleep deprivation for
  which the transcript Homer1a is a good candidate.  Comprehensive transcri
 ptome analyses confirmed a role of Homer1a in sleep homeostasis.  The same
  analyses indicated that the genes known to set circadian time are also in
 volved in the homeostatic regulation of sleep.  We confirmed this in mice 
 lacking one or more of the core clock components. Thus at least at a cellu
 lar level the same molecular circuitry seems to be implicated in both circ
 adian rhythms and sleep homeostasis\, challenging the accepted notion that
  these processes are separate.
LOCATION:SV 1717a
STATUS:CONFIRMED
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