BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:IC Colloquium : Computing Cancer
DTSTART:20161128T161500
DTEND:20161128T173000
DTSTAMP:20260408T002501Z
UID:516ef9d184e4dbb780e3c3257ed0644c7caa44f17d7ef647e94e30f5
CATEGORIES:Conferences - Seminars
DESCRIPTION:By : Jasmin Fisher - University of Cambridge & Microsoft Resea
 rch\n\nAbstract :\nCancer is a highly complex cellular state where mutatio
 ns impact a multitude of signalling pathways operating in different cell t
 ypes. In recent years it has become apparent that in order to understand a
 nd fight cancer\, it must be viewed as a system\, rather than as a set of 
 cellular activities. This mind shift calls for new techniques that will al
 low us to investigate cancer as a holistic system. In this talk\, I will d
 iscuss some of the  progress made towards achieving such a system-level u
 nderstanding using executable modelling of biological  behaviours\, also 
 known as Executable Biology. I will concentrate on our efforts to better 
 understand aberrant signalling in leukaemias and solid cancer through the 
 following examples: drug target optimization and combination therapies to 
 fight Chronic Myeloid Leukaemia and Acute Myeloid Leukaemia using an innov
 ative platform called BioModelAnalyzer\, which allows to prove stabilizat
 ion of biological systems\; spatial hybrid modelling of Glioblastoma (brai
 n tumour) development\; state-based modelling of cancer signalling crossta
 lks and their analysis using model-checking\; and reconstruction of blood 
 stem cell programs from single-cell gene expression data using program syn
 thesis. These kind of executable signalling programs further help us ident
 ify and understand the driver mechanisms of cancer\, which will eventually
  pave the way for better detection\, diagnosis\, and treatment of patients
 \, at an individual level.\n\nBio :\nJasmin Fisher is an Associate Profess
 or of Systems Biology in the Department of Biochemistry at the Universi
 ty of Cambridge. She is also a Senior Researcher at Microsoft Research Ca
 mbridge in the Programming Principles & Tools group. She is a member of
  the Cambridge Cancer Centre\, Cambridge Systems Biology Centre and the
  Cambridge Stem Cell Institute\, and in 2016 she was elected Fellow of T
 rinity Hall\, Cambridge. Jasmin received her PhD in Neuroimmunology from t
 he Weizmann Institute of Science in 2003. She then started her work on the
  application of formal methods to biology as a postdoctoral fellow in the 
 Department of Computer Science at the Weizmann Institute (2003-2004)\, wh
 ere she worked with David Harel\, and then continued to work on the develo
 pment of novel formalisms and tools that are specifically-tailored for mod
 elling biological processes as a postdoctoral researcher in the School o
 f Computer Science at the EPFL in Switzerland (2004-2007)\, together with
  Tom Henzinger. In 2007\, Jasmin joined the Microsoft Research Lab in Cam
 bridge. In 2009\, she was also appointed a Research Group Leader in the Un
 iversity of Cambridge. Jasmin has devoted her career to develop methods fo
 r Executable Biology\; her work has inspired the design of many new biolog
 ical studies. She is a pioneer in using formal verification methods to ana
 lyze mechanistic models of cellular processes and disease. Her research gr
 oup focuses on cutting-edge technologies for modelling the molecular mecha
 nisms of cancer and the development of novel drug therapies\, currently al
 so in use by the pharmaceutical industry.\n\nMore information  
LOCATION:BC 420 https://plan.epfl.ch/?room==BC%20420
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR