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PRODID:-//Memento EPFL//
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SUMMARY:Brain water transport: A key role for AQP4 – or not?
DTSTART:20111125T120000
DTSTAMP:20260428T010014Z
UID:f57b9840866ccd076c5c4bf699cc0789a3b98f134cb794b455829510
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof.  Nanna MacAulay\, Department of Cellular and Molecular M
 edicine\, Faculty of Health Sciences\, University of Copenhagen\nThe water
  in the mammalian brain is continuously shifted between the circulating bl
 ood\, the cerebrospinal fluid\, and the brain parenchyma as well as betwee
 n different compartments and cellular structures within the brain tissue. 
 The molecular mechanisms responsible for the maintenance of the cerebral w
 ater homeostasis are poorly understood and so is their involvement in the 
 glial and neuronal cell swelling observed during stroke. Substances such a
 s vasopressin and glutamate are released during cerebral ischemia and cont
 ribute to the associated brain water accumulation and cell swelling. This 
 has been proposed to take effect by short-term regulation of aquaporin 4 (
 AQP4) via phosphorylation. \n\nThe talk will focus on the lack of evidence
  in favor of phosphorylation-dependent gating of AQP4. An alternative mode
  of water transport across cell membranes will be introduced as the keeper
  of brain water homeostasis\; cotransport of water. Water transport by thi
 s alternative pathway is independent of the osmotic gradients strictly req
 uired for AQP-dependent water flux as it cotransports water along with the
  translocation of substrate.
LOCATION:SV1717A
STATUS:CONFIRMED
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