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SUMMARY:“Extreme value statistics in selection from minimal antibody lib
 raries”
DTSTART:20161014T140000
DTEND:20161014T153000
DTSTAMP:20260509T234144Z
UID:603cca1cfbdccc13e9153e7d23bc5cd381340c9220e6022d7bdc5276
CATEGORIES:Conferences - Seminars
DESCRIPTION:Olivier Rivoire\nTo study quantitatively and at a molecular 
 level how the diversity of a population relates to its capacity to respon
 d to selection\, we built several minimal antibody libraries and selecte
 d them in vitro to bind to specific targets. I will present our analysi
 s of these experiments\, which combine antibody phage display with high-
 throughput sequencing. In particular\, I will show how an elementary prob
 abilistic model based on extreme value theory accounts for the diversity o
 f results that we obtain. Our work has several potential implications for 
 designing synthetic protein libraries\, for estimating the density of func
 tional biomolecules in sequence space\, for characterizing diversity in na
 tural populations and for experimentally investigating the concept of "evo
 lvability ».
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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