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SUMMARY:Bacteria as Vectors – Imaging and Therapeutic Potential for Canc
 er and Beyond
DTSTART:20111114T103000
DTSTAMP:20260405T204810Z
UID:18818186803f6d0479b3f849ad7c92b38d0b283de722a76501655b80
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Mark Tangney\n"Bacteria present an attractive class of g
 ene vector for cancer\, possessing a natural ability to grow specifically 
 within tumours following systemic administration. We describe a range of s
 trategies under investigation by our group\, designed to exploit tumour-sp
 ecific bacterial replication\, utilising both non-pathogenic and pathogeni
 c/invasive bacterial vectors. We have engineered a number of replication-c
 ompetent non-pathogenic probiotic bacteria to express heterologous genes a
 nd mediate long-term production of agents within tumour masses (external t
 o tumour cells) following systemic administration. Use of safety attenuate
 d invasive strains permits intracellular DNA\, RNA or protein delivery. Lu
 minescent reporter gene (bacterial lux) tagging permits real-time tracking
  of vector without the need for substrate administration\, with high-resol
 ution detail of in vivo bacterial growth within deep tissue achieved using
  3D BLI tomography. We have demonstrated that the various vectors can be e
 xploited in a wide range of therapeutic strategies and tumour models\, pre
 senting a powerful and safe approach to specific gene/cell therapy of prim
 ary tumours and secondary metastases."
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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