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SUMMARY:The interaction of blood flow and drug release for cardiovascular 
 drug eluting stents and the numerical treatment of net flux boundary condi
 tions
DTSTART:20090213T110000
DTSTAMP:20260924T181318Z
UID:b5ac6c855ab591c407cf1780d20a33de51d539d88110db0437f7dc6f
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Paolo Zunino\nMass transport driven by intramural plasma
  filtration is the basic process to supply nourishment to the tissues of m
 edium/small size arteries. In the last decades\, this process has also bee
 n exploited to deliver drugs to arteries affected by atherosclerotic patho
 logies\, such as coronary arteries. Drug eluting stents represent a recent
  and widespread example of this procedure. The design of these devices req
 uires first of all to determine the correct drug dosage and release rate\,
  which mainly depend on the transport properties of the substrate releasin
 g the drug as well as on the biochemical interaction between the drug and 
 the arterial tissue. More recently\, preliminary computational studies hav
 e put into evidence that blood flow local features and drug deposition int
 o the artery are correlated. These phenomena may also significantly intera
 ct with intramural plasma filtration. However\, to our knowledge\, such in
 terplay has not yet been deeply investigated.\nThis study requires to perf
 orm classical hemodynamics simulations in specific\, very localized vascul
 ar districts. It is well known that one of the main difficulties of such a
 nalysis is the prescription of suitable boundary conditions on the artific
 ial inflow and outflow sections of the considered district. The applicatio
 n of net flux defective boundary conditions provides an effective solution
  to this difficulty. In the second part of this work\, we discuss an effic
 ient way to account of such conditions into standard finite element scheme
 s for incompressible flows. \nAfter a brief review of the problem and of i
 ts well posedness\, we discretize the corresponding variational formulatio
 n by means of finite elements and looking at the boundary conditions as co
 nstraints\, we exploit a penalty method to account for them. 
LOCATION:MAA112
STATUS:CONFIRMED
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