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SUMMARY:Resequencing DNA microarray: A powerful tool for identification of
  known and novel emerging pathogens?
DTSTART:20090216T110000
DTSTAMP:20260406T224655Z
UID:dbc8c3510c48eeff90e41985df47e74efebeef72cf7d1fbf7be28010
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr Nicolas Berthet (Institut Pasteur)\nThe development of DNA 
 microarray as diagnostic tool for identification of pathogens offers inter
 esting perspectives. Indeed\, this technology allows unbiased and simultan
 eous identification of a huge number of bacterial and viral agents. In thi
 s case\, the use of resequencing DNA microarray allows to obtain more prec
 ise identification of pathogens and to enlarge the detection spectrum in c
 omparison with classical microarray. Until nowadays\, this resequencing mi
 croarray was poorly exploited for diagnostic of infectious disease\, parti
 cularly in virology. The aim of our work consisted to develop and validate
  resequencing microarray for identification of a large series of bacterial
  and viral pathogens originating from diverse biological samples. Based on
  the Affymetrix technology\, two successive generations of microarrays wer
 e developed for detection of both bacterial agents\, associated to their p
 athogenicity genes and their conferring antibiotic resistances\, and viral
  agents. Our results demonstrated the interest of this technology for path
 ogens identification in different clinical situations. Moreover\, discrimi
 nation capacity of this microarray was showed for the detection of close v
 ariants or for identification of novel variants attached to a viral family
 . All together\, our results confirmed advantages of this technology in th
 e virology field and open novel routes of optimisation for the development
  of a third generation of microarray with enlarged spectrum of viral detec
 tion.
LOCATION:AI 1153 https://plan.epfl.ch/?room==AI%201153
STATUS:CONFIRMED
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