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PRODID:-//Memento EPFL//
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SUMMARY:Small RNA Silencing in Drosophila
DTSTART:20090424T121500
DTSTAMP:20260407T175819Z
UID:463dcb5f534977eb66b95113d91c8a251bf3b855fcdbfc0a35d831b0
CATEGORIES:Conferences - Seminars
DESCRIPTION:Klaus Förstemann\nThe discovery of gene silencing through miR
 NAs and siRNAs was an important addition both to our understanding of gene
  regulation and as a tool to study gene function. Additional classes of sm
 all silencing RNAs were discovered through “deep sequencing” technolog
 ies\; they appear to protect our genome from the mobilization of selfish g
 enetic elements in somatic tissues as well as in the germline. The high co
 py number and repetitive nature of such elements is shared by stably integ
 rated expression constructs that are frequently used in cell culture. This
  has allowed us to study the de novo generation of such a silencing respon
 se\, its mechanism of repression and to analyze specific protein factors w
 hich are required for the repression of repetitive elements by small RNAs.
  
LOCATION:SV 1717A
STATUS:CONFIRMED
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