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SUMMARY:DEP-Wells: a New Paradigm for Cell Separation and Analysis
DTSTART:20161024T101500
DTEND:20161024T111500
DTSTAMP:20260405T163735Z
UID:835a862118485a0e440a2eb991ff8ab2554a20df14c9786daddf640e
CATEGORIES:Conferences - Seminars
DESCRIPTION:Professor Michael P. Hughes\, University of Surrey\, Guildford
  (UK)\nBIOENGINEERING SEMINAR\n\nAbstract:\nDielectrophoresis (DEP) was sh
 own to discriminate between cells according to their electrical properties
 \, and separate them\, fifty years ago.   Numerous technological develop
 ments have since improved the sensitivity of cell analysis\, or the throug
 hput of cell separators\, but none have reached the throughput of more com
 mon cell analysis platforms such as flow cytometry/FACS.  We have develop
 ed a new paradigm for DEP cell separation and manipulation based on interl
 eaved conductors and insulators\, through which “wells” are then forme
 d.  Cells within these wells experience attraction the sides or repulsion
  into the centre. The rate of movement\, if measured for the cell ensemble
 \, can yield the net properties of the population at the energising freque
 ncy\; alternatively\, if cells are passed through the well\, they can be s
 eparated.  Studies show unprecedented levels of accuracy and throughput\;
  analyses of 20\,000 cells can be determined in 10 seconds\, with up to fo
 ur subpopulations being detectable.  100-point spectra can be produced in
  minutes\, for unprecedented accuracy.  Blood can be analysed within seco
 nds of drawing.  Applications range from IC50 measurement to the study of
  apoptosis\, for cancer diagnosis to new findings in circadian biology.  
 We have also separated mixtures of live and dead yeast\, or blood and canc
 er cells\, at rates of up to 150\,000 cells/second.  100 million cells ca
 n be sorted in 15 minutes\, with separation efficiencies and purities of 9
 5% and cell losses of 5%\, without the use of labels.  Collectively\, the
 se technologies have the potential to make DEP a future staple of laborato
 ry practice.\n\nBio:\nHailing from Holy Island off the Welsh coast\, Profe
 ssor Michael Pycraft Hughes was appointed Professor of Biomedical Engineer
 ing in 2008 after joining the University of Surrey as a lecturer in 1999. 
  His 20-year research career has focussed on the development of dielectro
 phoresis (DEP) – a force causing particles to move in non-uniform electr
 ic fields.  His work relates primarily to the development of DEP-based as
 says. DEP can be used to analyse\, and selectively move or separate micro-
  and nano-particles\, and has been applied to cancer cells\, bacteria\, st
 em cells\, yeast\, DNA\, viruses\, carbon nanotubes and nanowires\, and wh
 ich has led to the founding of a spin-out company to commercialise DEP tec
 hnology (see “research interests” below). He also has broader interest
 s in electric fields and cells at the microscale\, and has published work 
 with DSTL on sensor enhancement using microfluidics (which resulted in thr
 ee patent applications)\, microelectrode devices for neural sensing\, and 
 simulations of laser removal of tattoos. He has written or co-written over
  50 journal publications (making him one of the most published authors in 
 the field of DEP) and two books\, and has presented invited talks in the U
 K\, US\, France\, Spain\, China and India. He has been the Editor in Chief
  of IEEE Transactions on Nanobioscience since 2008 (Senior Editor 2005-200
 7)\, and serves as committee member for the Institute of Physics Dielectri
 cs Society\, the IEEE Nanotechnology Council\, the International Council f
 or Science Working Group on Nanomaterials\, and the Engineering in Medicin
 e and Biology Society.   Since 2008\, Mike has been Director of the Centr
 e for Biomedical Engineering at the University of Surrey\, one of the olde
 st since centres in the world (the first appointment having been made in 1
 965).  From 2008-2012\, he also acted as Course Director of the MSc progr
 amme in Biomedical Engineering at Surrey (running since 1966) and from 200
 1-12 acted as course lead for the B/MEng Medical Engineering programmes. 
  
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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