BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:Diffusion MRI monitoring of microstructure in the irradiated rat b
 rain
DTSTART:20161214T140000
DTEND:20161214T150000
DTSTAMP:20260427T200313Z
UID:5c8492d08e8b366000ef52a5cb1912ba290f036a333ea99acfb80ed3
CATEGORIES:Conferences - Seminars
DESCRIPTION:Julie Constanzo\nMetastatic brain tumors\, which are typically
  well circumscribed\, often provide an ideal target for stereotactic radio
 surgery (SRS). The goal of SRS is to limit tumor growth while minimizing t
 he risk of long-term neurotoxic or cognitive side effects. However\, imple
 menting SRS can be difficult given that during treatment\, surrounding hea
 lthy tissue will inevitably receive a significant dose of radiation. This 
 may lead to clinical complications\, such as delayed formation of edema in
  the irradiated volume\, and in some cases\, to necrosis. Despite substant
 ial improvements in diffusion MRI (dMRI) metrics\, including diffusion ten
 sor imaging (DTI) and high angular resolution diffusion imaging (HARDI)\, 
 analysis of biological and microstructural properties remains challenging.
  HARDI in particular has the potential of elucidating abnormal connectivit
 y in axonal path disorder but also in grey matter where the complexity of 
 fiber bundles is poorly understood.\n\nWe developed a radiation necrosis m
 odel with a lesion located mainly into the white matter and the primary mo
 tor cortex (M1) of the right hemisphere of the rat brain. In this model we
  investigated whether dMRI indices correlated with histopathology and beha
 vioral changes.\n\nBio: Since December 2015\, Julie Constanzo hold a resea
 rch scientist position (3 years) in the department of Hadrontherapy\, Radi
 obiology and Molecular Imaging (DHRIM) at Institut Pluridisciplinaire Hube
 rt Curien\, CNRS\, University of Strasbourg\, France. She obtained her PhD
  degree at University Claude Bernard\, Lyon 1 in 2013\, where she conducte
 d dosimetry\, irradiation and radiobiological studies with protons and car
 bon ions at cellular level. Then\, she completed her postdoctoral fellow i
 n the department of Nuclear Medicine and Radiobiology at University of She
 rbrooke\, Canada in 2014\, performing preclinical studies. Julie Constanzo
  acquired both physics and biology skills as dosimetry\, irradiation\, ani
 mal model\, imaging application\, histopathology and behavioral tests. Usi
 ng a translational approach\, the aim of its work is to better understand 
 radiation-induced adverse effects in the brain to improve treatment planni
 ng\, patient management\, and to develop new therapeutic strategies in a c
 lose collaboration with radiation oncologists.
LOCATION:BC 03 https://plan.epfl.ch/?room==BC%2003
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR