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SUMMARY:An evolutionary switch in J-protein biology affects prokaryotic an
 d eukaryotic protein disaggregation
DTSTART:20161115T141500
DTEND:20161115T160000
DTSTAMP:20260509T234137Z
UID:a8acd1b579e55fb3de2374fa98988579f471a819073cd567e39f42b2
CATEGORIES:Conferences - Seminars
DESCRIPTION:Nadinath Nillegoda\, Heidelberg University\, Germany\nBIOLOGIC
 AL & STATISTICAL PHYSICS SEMINAR\n\nAbstract:\nDecreased cellular capacity
  in protein aggregate clearance manifests in cellular deterioration\, agin
 g and disease. Toxic intracellular aggregates formed by misfolded proteins
  are reversed and/or limited by multi-tiered cellular quality control syst
 ems.\n\nWe recently reported J-proteins of classes A and B cooperate via i
 nterclass complex formation to mediate substrate specificity of Hsp70-base
 d aggregate solubilizing systems (disaggregases) in metazoa. What remains 
 unclear is whether these mixed class J-protein complexes occur also in non
 -metazoans given the fact that orthologs of both classes exist in bacteria
 \, fungi\, plant and protozoa. Using a broad set of experimental approache
 s\, we find a switching in J-protein biology at the prokaryote-to-eukaryot
 e transition where class members network allowing for the emergence of pow
 erful\, yet regulatable eukaryotic disaggregase systems.\n\nWe also descri
 be a naturally occurring strategy to correctly pair J-proteins of differen
 t types\, ensuing functional integrity within networks in expanded J-prote
 in families during rise of complex life.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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