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SUMMARY:Novel Determinants of the Hematopoietic Microenvironment in Develo
 pment and Homeostasis
DTSTART:20090109T133000
DTSTAMP:20260506T220728Z
UID:27fa91dfd88f9bf2c31d8a648b95a657c1a36f9d550724ca2fd5b63a
CATEGORIES:Conferences - Seminars
DESCRIPTION:Dr. Olaia Naveiras\nSeminar of the Institute of Bioengineering
 \n\nAbstract:\nThe promise of regenerative medicine depends on succeeding 
 at generating sufficient amounts of functional\, transplantable tissue by 
 reliably differentiating pluripotent stem cells through the paths of ontog
 eny\, or by efficiently expanding adult stem cells in vitro. For that purp
 ose\, the environmental cues responsible for cell fate decisions in vivo n
 eed to be deciphered and reproduced in vitro. We have focused on the hemat
 opoietic system as the best characterized stem cell model system\, and pre
 sent here two novel modulators of the embryonic and adult hematopoietic mi
 croenvironment: biomechanical forces\, and specifically shear stress\, as 
 hematopoietic determinants in the developing aorta\, and bone marrow adipo
 cytes as negative regulators of the hematopoietic milieu.
LOCATION:AI 1 153
STATUS:CONFIRMED
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