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SUMMARY:Wolbachia-mediated arbovirus transmission blocking in mosquitoes
DTSTART:20161206T121500
DTEND:20161206T131500
DTSTAMP:20260609T210827Z
UID:fa8bea0c71f1ccfab0e1b4eccd424095c89a6de4555c550d5966a271
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Steven Sinkins\, Centre for Virus Research\, University 
 of Glasgow\nThe intracellular inherited bacteria Wolbachia can block the t
 ransmission of dengue\, chikungunya and Zika viruses by Aedes mosquitoes\,
  and can also spread through host populations by manipulating their reprod
 uction. Wolbachia is now being deployed as a dengue control tool in a numb
 er of countries. We have now created and characterized a number of transin
 fected lines in Aedes aegypti and Ae. albopictus using a range of Wolbachi
 a strains\, and the results highlight the key role host factors play in de
 termining Wolbachia intracellular density and fitness parameters.\n\nOral 
 challenges were conducted with the dengue and Zika viruses and the degree 
 of transmission blocking varied widely with strain. wMel\, the strain curr
 ently being used for dengue control campaigns\, produced a comparatively l
 ow degree of transmission blocking\, and also showed susceptibility to los
 s after larval heat treatment. A proteomic quantification of the effects o
 f Wolbachia revealed unexpected perturbations in cholesterol transport and
  vesicular trafficking\, which could impact viral entry and replication. T
 reatment with a cholesterol binding agent reversed the dengue-blocking phe
 notype in Wolbachia-infected Ae. aegypti cells.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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