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SUMMARY:Can Engineered Micro-Scale Organotypic Models Predict Patient-Spec
 ific Responses?
DTSTART:20171016T121500
DTSTAMP:20260407T003717Z
UID:12c6716cecf63a22e6a0a430edcbeccf8992d66ed1a08ce9aef516c2
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. David J. Beebe\, University of Wisconsin\, Madison\, WI 
 (USA)\nDISTINGUISHED LECTURE IN BIOLOGICAL ENGINEERING\n(sandwiches served
 )\n\nAbstract:\nCell-based assays for the prediction of patient-specific c
 ancer response have not been widely adopted. However\, it is timely to ree
 valuate their use\, as numerous innovations\, including micro-scale organ-
 on-a-chip models\, may improve their predictive power and utility. We demo
 nstrate how different levels of organotypic complexity may be necessary to
  recapitulate patient response: 1) Co-culture of multiple myeloma cells an
 d stroma from a patient accurately predicts drug chemosensitivity. 2) Inva
 sion of prostate cancer cells into model ECMs allows stratification of pat
 ients independent of other biomarkers. 3) Organotypic vessels from patient
  endothelial cells differentially respond to anti-angiogenic therapy in re
 nal cell carcinoma. In addition\, I will present our recent explorations i
 nto “open microfluidics” and its potential to advance the practical ap
 plication of microfluidics.\n\nBio:\nEducation:\n    B.S.\, UW–Madis
 on\, Electrical Engineering\n    M.S.\, UW–Madison\, Electrical Engin
 eering\n    Ph.D.\, UW–Madison\, Electrical Engineering (Minor: Life
  Sciences)\, 1989-1994\n    UW–Madison\, Cancer Biology\, 2004-2009\
 n\nPositions/experience:\nClaude Bernard Professor of Biomedical Engineeri
 ng\nUniversity of Wisconsin-Madison\, 2014 – Present\n\nPresident\nSalus
  Discovery LLC\, Madison\, WI\, 2013 – Present\n\nDirector\nTasso\, Inc.
 \, Madison\, WI\, 2013 – Present\n\nJohn D. MacArthur Professor\nUnivers
 ity of Wisconsin-Madison\, 2012 – Present\n\nCo-Leader\, Tumor Microenvi
 ronment Program\nUW Carbone Cancer Center\, University of Wisconsin-Madiso
 n\, 2012 – Present\n\nProfessor\nUniversity of Wisconsin-Madison (Dept o
 f Biomedical Engineering)\, 2005 – Present\n\nAssociate Chair for Resear
 ch and Faculty Development\nUniversity of Wisconsin-Madison (Dept of Biome
 dical Engineering)\, 2009 – 2014\n\nChief Scientific Officer\nRatio (Mad
 ison\, WI)\, 2005 – 2014\n\nAssistant Professor\nUniversity of Illinois 
 at Urbana-Champaign (Dept. of Electrical Engineering & Beckman Institute)\
 , 1996 – 1999\n\nAssistant Professor\nLouisiana Tech University (Dept. o
 f Biomedical Engineering)\, 1994 – 1996\n\nElectrical Engineer\nKimberly
 -Clark\, 1987 – 1989\n\nResearch Description:\nBasic cell culture techni
 ques have changed little in almost a century. By far the most dominate for
 mat for cell culture is the Petri dish or similar (e.g. multi well plate).
  Slowly this is beginning to change as our ability to create materials\, g
 eometries and even systems at the cellular scale continues to grow and mat
 ure. At the same time\, the importance of the three-dimensional microenvir
 onment in cancer biology is increasingly demonstrated. We have begun to ex
 plore a variety of engineered in vitro microenvironments to probe the natu
 re of cell interactions that regulate cell behavior. These environments ra
 nge from in silico lineage models to three-dimensional co-culture construc
 ts to simple convective-free culture systems to high throughput assay syst
 ems. While our particular interests center around cancer biology\, the con
 structs have broad potential application across cell biology. Our goal is 
 a holistic approach to understanding cell behavior that integrates in vitr
 o cellular scale engineering to recapitulate important in vivo microenviro
 nmental characteristics in ways that provide biological insights\, aid in 
 diagnosis/treatment and enhance discovery.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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