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SUMMARY:BMI Seminar // Novel treatment strategies for deficient fear extin
 ction learning
DTSTART:20170308T121500
DTEND:20170308T131500
DTSTAMP:20260427T205905Z
UID:9668c8e44eef88fac2c32082d585a278e63903fe180811f5ae1920e2
CATEGORIES:Conferences - Seminars
DESCRIPTION:Nicolas Singewald\, Department of Pharmacology and Toxicology\
 , University of Innsbruck\, Austria\nWith existing treatments  of fear-\,
  anxiety- and trauma-related disorders -  the most prevalent mental disor
 ders -  a considerable proportion of patients shows  only partial long-t
 erm therapeutic benefit. A promising option in improving therapy is the ph
 armacological boosting of exposure-based therapy (EBT). I will show genera
 l concepts of  treatment improvement based on accumulating neuroscientifi
 c knowledge concerning the neurocircuitries and neurobiological mechanisms
  underlying fear learning and fear inhibition. Select examples of novel  
 strategies in augmenting fear extinction\, the central mechanisms of EBT. 
 underlying successful fear extinction\, will be presented\,  The examples
  discussed will include deep brain stimulation\, targeting micro RNAs\, as
  well drugs such as L‑DOPA\, D‑cycloserine and HDAC inhibitors to faci
 litate the building of extinction memory.  Neuropeptide S will be present
 ed as a model substance with anxiolytic and extinction-facilitating proper
 ties. The presented mechanisms represent promising drug development target
 s for augmenting the efficacy and improving the acceptance of EBT in the t
 reatment of anxiety disorders.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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