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SUMMARY:How Dieting Makes Some Fatter: from a Perspective of Adipostat(s) 
 and Proteinstat(s) Awaiting Discovery
DTSTART:20161206T130000
DTSTAMP:20260406T081500Z
UID:fcf7fabb530517b8fe166878af3194fec9f79de72e8b2d8a2085f92d
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Abdul Dulloo\, University of Fribourg (CH)\nBIOENGINEERI
 NG SEMINAR\n\nAbstract:\n‘Dieting makes you fat’ embodies the notion t
 hat dieting to control body weight predisposes the individual to acquire e
 ven more body fat. While this notion is controversial\, its debate undersc
 ores the large gap that exists in our understanding of basic physiological
  laws that govern the regulation of human body composition. A striking exa
 mple is the key role attributed to adipokines (e.g. leptin) as feedback si
 gnals between adipose tissue depletion and compensatory increases in food 
 intake. Yet\, the relative importance of fat depletion per se as a determi
 nant of post-dieting hyperphagia is unknown. On the other hand\, the quest
 ion of whether the depletion of lean tissues can provide feedback signals 
 on the hunger-appetite drive is rarely invoked\, despite evidence that foo
 d intake during growth is dominated by the impetus for lean tissue deposit
 ion\, amidst proposals for the existence of protein-static mechanisms for 
 the regulation of growth and maintenance of lean body mass. In fact\, a fe
 edback loop between fat depletion and food intake cannot explain why human
  subjects recovering from starvation continue to overeat well after body f
 at has been restored to pre-starvation values\, thereby contributing to 'f
 at overshooting'.\n\nIn addressing the plausibility and mechanistic basis 
 by which dieting may predispose to increased fatness\, this lecture integr
 ates the results derived from the re-analysis of classic longitudinal stud
 ies of human starvation and refeeding. These suggest that feedback signals
  from the depletion of both fat mass (i.e. adipostats) and FFM (i.e. prote
 instats) contribute to weight regain through the modulation of adaptive th
 ermogenesis and energy intake\, and that a faster rate of fat recovery rel
 ative to FFM recovery (i.e. preferential catch-up fat) is a central outcom
 e of body composition autoregulation that drives fat overshooting. This co
 nfers biological plausibility for post-dieting fat overshooting - which th
 rough repeated dieting and weight cycling would increase the risks for tra
 jectories from leanness to fatness. It also provides a system-physiology f
 ramework towards a more comprehensive molecular understanding of the senso
 r(s)\, signal(s) and effector(s) that constitute the adipostatic and prote
 inostatic control of body composition\, with major implications for the ma
 nagement of obesity and cachexia.
LOCATION:AI 1 153 http://map.epfl.ch/?room=ai1153
STATUS:CONFIRMED
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