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SUMMARY:Qualitatively-different mitochondrial fusion in POMC neurons diver
 gently regulates energy balance and glucose homeostasis
DTSTART:20170327T133000
DTEND:20170327T143000
DTSTAMP:20260924T045307Z
UID:8d0af1f20469a95bd3e55f3bef65905015abda22113b7e371201f53c
CATEGORIES:Conferences - Seminars
DESCRIPTION:Marc CLARET IDIBAPS\, Barcelona\, Spain\nSEMINAR SERIES :  Tr
 ends in Physiology and Metabolism (Bio-682)\n\nAbstract:\nPro-opiomelanoco
 rtin (POMC) neurons in the arcuate nucleus (ARC) of the hypothalamus are c
 ritical regulators of appetite\, energy expenditure and glucose metabolism
 . POMC neurons are able to sense circulating hormones and nutrients inform
 ing about the energy status of the organism. However the molecular mechani
 sms underlying nutrient-sensing in POMC neurons remain incompletely unders
 tood.\nMitochondria are key organelles implicated in cellular nutrient/ene
 rgy management and are able to bioenergetically adjust to different metabo
 lic situations. A remarkable feature of mitochondria is their capacity to 
 change their morphology through coordinated fusion and fission events\, a 
 mechanism that links nutrient availability with bioenergetic adaptations. 
 Mitochondrial fusion is a process that requires the GTPases mitofusin (Mfn
 ) 1\, Mfn2 and OPA1. We hypothesized that mitochondrial fusion in hypothal
 amic POMC neurons may represent primary nutrient/energy-sensing processes 
 implicated in the hypothalamic regulation of energy balance and metabolism
 .\nTo test this hypothesis we have generated mice lacking the main fusogen
 ic proteins specifically in POMC neurons and conducted detailed phenotypin
 g and molecular studies. Our data demonstrate divergent metabolic outcomes
  depending on the deleted fusion protein\, which are mediated by different
  tissues and molecular processes. These results suggest that mitochondrial
  dynamics in POMC neurons is a critical mechanism implicated in the mainte
 nance of systemic energy balance and glucose homeostasis.
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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