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SUMMARY:Metabolic control of aging
DTSTART:20170410T133000
DTEND:20170410T143000
DTSTAMP:20260510T164824Z
UID:368c0355cf2b91f4c6b5e49ee751263963d35042c408afb5781fffbc
CATEGORIES:Conferences - Seminars
DESCRIPTION:Michael RISTOW ETH Zürich\, Switzerland\nSEMINAR SERIES :  T
 rends in Physiology and Metabolism (Bio-682)\n\nAbstract:\nProcessing and 
 intermediate metabolism of macronutrients are essential components of any 
 life. Facultative or obligatory conversion of carbohydrates as well as fat
 ty and amino acids into readily available energy equivalents like ATP are 
 tightly regulated. Our interest is focused on the role of specific amino a
 cids and glucose metabolites on nematodal and murine lifespan. Downstream 
 oxidative metabolism of fatty and amino acids\, as well as glycolytic deri
 vatives like pyruvate occurs in the mitochondria. Reactive Oxygen Species 
 (ROS) are considered inevitable by-product of mitochondrial metabolism\, a
 nd are known to exert diverse signaling roles since the late 1990ies.  We
  and others have shown since then that increased ROS formation is required
  for extension of C. elegans lifespan in states of calorie restriction\, i
 mpaired insulin/IGF-1 signaling in daf-2 mutants\, inhibition of component
 s of the respiratory chain\, and lastly sirtuin/sir-2.1 signaling.  Conve
 rsely\, supplementation of antioxidants or overexpression of ROS-detoxifyi
 ng enzymes to impair ROS signaling blocks the lifespan-extending capabilit
 ies of the aforementioned interventions and genetic modifications.  These
  health-promoting roles of ROS have been named mitohormesis and also apply
  to humans.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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