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SUMMARY:Non-coding genome function and diabetes
DTSTART:20170424T133000
DTEND:20170424T143000
DTSTAMP:20260407T163516Z
UID:156c24859519cc0dcf67b146ae757138e61e8ab612ea432b34c94c9e
CATEGORIES:Conferences - Seminars
DESCRIPTION:Jorge FERRER Imperial College\, London\, UK & Genomic Programm
 ing of Beta-cells Laboratory\, Institut d'Investigacions August Pi I Sunye
 r (IDIBAPS)\, CIBERDEM\, Barcelona\, Spain\nSEMINAR SERIES:  Trends in Ph
 ysiology and Metabolism (Bio-682)\n\nAbstract:\nMost genetic mechanisms th
 at are currently known to underlie developmental processes and human disea
 ses are based on the analysis of a very small fraction of the genome that 
 encodes for protein-coding sequences. However\, recent studies have uncove
 red large portions of the genome that contain functional regulatory elemen
 ts and noncoding transcripts. It is thus reasonable to presume that unders
 tanding the function of such elements can shed new light into developmenta
 l and cellular mechanisms\, and uncover new causes of human disease. The e
 lucidation of noncoding defects will require knowledge of the genomic loca
 tion of functional noncoding elements in disease-relevant cell types\, as 
 well as an in depth understanding of how they function. I will discuss how
  integrative human islet chromatin maps can provide novel insights into ho
 w the islet epigenome shapes cell-specific transcriptional programs. Exist
 ing data suggests that variation in islet lncRNAs and long-range regulator
 y elements contributes to the molecular mechanisms underlying human diabet
 es.\n\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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