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SUMMARY:Making Use of 'Omics: From Systems Genetics to Cell Biology
DTSTART:20170529T133000
DTSTAMP:20260928T184404Z
UID:0b79be36fb8d01a14aad40717d0ff25ba0a43622876bf8b21708d89f
CATEGORIES:Conferences - Seminars
DESCRIPTION:Evan WILLIAMS ETH Zürich\, Switzerland\nSEMINAR SERIES :  Tr
 ends in Physiology and Metabolism (Bio-682)\n\nAbstract:\nOne of the funda
 mental tenants of biology tells us that DNA is transcribed into RNA\, whic
 h is translated into protein\, which affect the levels of the metabolites 
 which carry out cellular actions. Microarrays and nucleotide sequencing te
 chnologies have made the measurement of DNA and RNA trivial\, genome-wide\
 , and accurate\, yet the relationships between the layers of DNA\, RNA\, p
 rotein\, and metabolites remain complex and unpredictable—i.e. measuring
  a gene's RNA level is of mediocre predictive value for its associated pro
 tein. Recently\, mass spectrometry (MS)-based technologies have been refin
 ed to the point where quantitative\, reliable\, systems-scale measurements
  of the proteome and metabolome have become possible. Thus\, recent system
 s biology studies have begun to focus on "multi-omics" studies—combining
  and comparing the data of the transcriptome\, proteome\, and metabolome a
 nd how these layers correspond to the phenotype of interest.\nIn this lect
 ure\, we will in particular examine how SWATH-MS\, a next-generation prote
 omics technique\, can be run across a large and diverse population to unco
 ver new insights on mitochondrial protein localization\, the stoichiometry
  of oxidative phosphorylation. With these new technologies\, we can begin 
 to develop and test novel hypotheses and design validation experiments tha
 t were previously infeasible.\n\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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