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SUMMARY:The Power of Miniaturization in Medicine: Engineered Hepatic Tissu
 es and Cancer Nanotechnology
DTSTART:20170329T103000
DTSTAMP:20260427T230905Z
UID:16064158f3c21153a6c0cd7e4da65446399352888b74533cd4649f14
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Sangeeta N. Bhatia\, Massachussets Institute of Technolo
 gy\, Cambridge\, MA (USA)\nDISTINGUISHED LECTURE IN BIOLOGICAL ENGINEERING
 \n\nAbstract:\nOur laboratory studies how micro- and nanoscale systems can
  be deployed to understand\, diagnose\, and treat human disease.  In this
  talk\, I will describe our progress in two application areas:  liver dis
 ease and cancer.\nIn the area of hepatic tissue engineering\, we are devel
 oping microtechnology tools to understand how ensembles of cells coordinat
 e to produce tissues with emergent properties in the body. We have used th
 is understanding to fabricate human microliver tissues in both '2D' and '3
 D' formats that enable us to study host-pathogen interactions in hepatitis
  and malaria.\nIn the area of cancer\, we are developing nanotechnology to
 ols to meet the challenge of delivering cargo into the tumor microenvironm
 ent where transport is dominated by diffusion. Our strategy is to design n
 anotechnologies which emulate nature's mechanisms of homing\, activation\,
  and amplification to deliver cytotoxic drugs\, diagnostic tools\, imaging
  agents\, and siRNA to tumors.\nThus\, using nature as a guide\, we are es
 tablishing a framework for building systems from micro- and nanoscale comp
 onents that function collectively to treat human disease.\n \nBio:\nTrain
 ed as both a physician and engineer\, Dr. Bhatia has pioneered technologie
 s for interfacing living cells with synthetic systems\, enabling new appli
 cations in tissue regeneration\, stem cell differentiation\, medical diagn
 ostics and drug delivery. Her multidisciplinary team has developed a broad
  and impactful range of inventions\, including human micro livers which mo
 del human drug metabolism\, liver disease\, and interaction with pathogens
 \, and a suite of communicating nanomaterials that can be used to interrog
 ate\, monitor and treat cancer and other diseases. Her work has been profi
 led broadly such as in Scientific American\, the Boston Globe\, Popular Sc
 ience\, Forbes\, PBS’s NOVA scienceNOW\, The Economist\, and MSNBC.\nDr.
  Bhatia trained at Brown\, MIT\, Harvard\, and MGH. She is an elected memb
 er of the National Academy of Engineering and the American Academy of Arts
  and Sciences\, and she is a fellow of the Massachusetts Academy of Scienc
 es\, the Biomedical Engineering Society\, the American Institute for Medic
 al and Biological Engineering\, and the American Society for Clinical Inve
 stigation. She has been awarded the 2015 Heinz Award for Technology\, the 
 Economy and Employment\; the 2014 Lemelson-MIT Prize\; the David and Lucil
 e Packard Fellowship given to “the nation’s most promising young profe
 ssors in science and engineering\;” the NSF CAREER Award\; the Y.C. Fung
  Young Investigator Award of the American Society of Mechanical Engineers\
 ; the Young Investigator Award of the American College of Clinical Pharmac
 ology\; and the Brown Engineering Alumni Medal. She also was named a Merki
 n Fellow of the Broad Institute.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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