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SUMMARY:fMRI in Rodents –  from Bold Activity Readouts to Large Scale Ne
 tworks Interactions
DTSTART:20170130T121500
DTSTAMP:20260916T050005Z
UID:56d75687eea8de9d8afe78fc8bf85a9c25d579c3e0b594ef32498870
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Markus Rudin\, Institute for Biomedical Engineering\, ET
 HZ\, Zurich (CH)\nDISTINGUISHED LECTURE IN BIOLOGICAL ENGINEERING\n(sandwi
 ches served)\n\nAbstract:\nFunctional magnetic resonance imaging (fMRI) in
  rodents is attractive in many regards. Mechanistic information on the lin
 k of the hemodynamic response to the underlying neural activity can be obt
 ained by combining fMRI with established invasive readouts of neuronal fun
 ction. Use of genetically engineered mouse lines allows assessing the impa
 ct of specific molecular entities involved in signal processing. The relat
 ively simple (cortical) morphology enables detailed analyses of the functi
 onal topology and its rearrangements following CNS injury and full three-d
 imensional brain coverage the identification of large scale networks invol
 ved in a specific task\, during pharmacological activation or at rest.\n\n
 Challenges in rodent fMRI are linked to the small dimensions and correspon
 ding high demands on spatial resolution\, to the animal physiology\, which
  should be stable enough to allow for detection of percent changes in sign
 al intensity\, and to the potential interference by anesthesia. Technical 
 solutions are available and rodent (mouse) fMRI is becoming a commodity.\n
 \nDifferent aspects of rodent fMRI will be addressed: 1) Mechanistic infor
 mation on the neurovascular coupling obtained by combined fMRI with comple
 mentary activity readouts\, 2) structural and functional connectivity in m
 ouse brain\, 3) dynamic aspects of functional connectivity\, 4) investigat
 ion neurotransmitter networks using optogenetic approaches\, and 5) analys
 is of the impact of pathological conditions such as cerebral amyloidosis m
 imicking aspects of Alzheimer’s disease\, chronic psychosocial stress (C
 PS)\, and early life stress on brain functional networks.\n\nBio:\nMarkus 
 Rudin is full professor for Molecular Imaging and Functional Pharmacology 
 at the Institute for Biomedical Engineering (D-ITET) since June 2006. Sinc
 e March 2005 he is also full professor for Molecular Imaging and Functiona
 l Pharmacology at the University of Zürich both at the Institute for Biom
 edical Engineering and the Institute for Pharmacology and Toxicology.\nMar
 kus Rudin (born 1953\, from Lauwil BL) received his diploma in chemistry a
 t the ETHZ in 1976 and his PhD at the Laboratory for Physical Chemistry in
  1981 in the field of electron spin resonance / electron-nuclear double re
 sonance\, followed by a post-doctorate in the same area. In 1983 he moved 
 to biomedical imaging\, joining Sandoz AG to build up a biomedical imaging
  group initially focused on magnetic resonance imaging. He received his ba
 sic training in imaging at the Biocenter of the University of Basel. Withi
 n Sandoz AG\, later Novartis Pharma AG\, he became head of the Biophysics 
 Group\, head of the In-vivo Models Unit and finally head of the Analytical
  and Imaging Science Unit within Discovery Technologies at the Novartis In
 stitutes for Biomedical Research. In this function he was also deputy head
  of Discovery Technologies until 2005. In 1997 he became Privat Dozent for
  Biophysics at the University of Basel. Since March 2005\, he is member of
  the Research Council of the Swiss National Science Foundation.\nMarkus Ru
 din is heading a research group at the animal imaging center of UZH and ET
 H located at ETH Hönggerberg focusing on MRI and optical imaging methods 
 (fluorescence tomography). His research focus is the development of non-in
 vasive imaging techniques for studying structure\, physiology\, and metabo
 lism of tissue as well as cellular and molecular events in the intact orga
 nism\, in particular assays for monitoring signal transduction pathways. B
 iomedical applications are in neuroscience and metabolic diseases.\n 
LOCATION:SV 1717 https://plan.epfl.ch/?room==SV%201717
STATUS:CONFIRMED
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