BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Memento EPFL//
BEGIN:VEVENT
SUMMARY:Cytoskeletal intermediate filaments - from Self-Assembly to Cell M
 echanics
DTSTART:20170501T131500
DTEND:20170501T141500
DTSTAMP:20260414T105934Z
UID:1d00d932125d2e5f40275559c829eebe8922c0c5cb1798721497e59c
CATEGORIES:Conferences - Seminars
DESCRIPTION:Prof. Sarah Köster\, University of Göttingen\, Germany\nBiol
 ogical cells are pervaded by a dense biopolymer network of fibrous protein
 s\, collectively termed the cytoskeleton. The exact structures comprising 
 this composite network are majorly important for the mechanical properties
  of the cells\, which in turn support their physiological function. The cy
 toskeleton consists of three filamentous systems\, actin filaments\, micro
 tubules and intermediate filaments (IFs) along with a plethora of binding 
 proteins and molecular motors. Among the three filamentous systems\, IFs s
 elf-assemble in a highly hierarchical process giving rise to a very partic
 ular molecular architecture. IFs are expressed in a cell type specific man
 ner and are thus being discussed as strong candidates for the precise defi
 nition of the different mechanical properties of different cell types.\n\n
 Our research focuses on the relation between molecular structure and mecha
 nical properties of filaments and cells. I will present state-of-the art e
 xperiments and recent results on the self-assembly of the proteins into fi
 laments and networks and their intriguing mechanical properties. The relev
 ant length scales for these processes range between few nanometers and man
 y micrometers. Therefore\, we employ small angle x-ray scattering (SAXS)\,
  x-ray nano-diffraction\, static and dynamic light scattering (SLS/DLS)\, 
 fluorescence correlation spectroscopy (FCS)\, optical tweezers\, and fluor
 escence microscopy. As some of these methods are inherently slow and thus 
 provide only a low time resolution\, we combine the observation techniques
  with microfluidics to obtain in situ data.\nReferences\n(Review papers\, 
 I think those are best suited):\n[1]  J. Block\, V. Schroeder\, P. Pawlzy
 k\, N. Willenbacher\, S. Köster\, BBA Mol Cell Res 2015\, 1853\, 3053-64.
 \n[2]  S. Köster\, D. Weitz\, R. Goldmann\, U. Aebi\, H. Herrmann\, Curr
  Opin Cell Biol 2015\, 32\, 82-91\n(one recent research paper is just in p
 ress\, should come out in the next few days):\n[3]  J. Block\, H. Witt\, 
 A. Candelli\, E. Petermann\, G. Wuite\, A. Janshoff\, S. Köster Phys. Rev
 . Lett. 2017\, accepted for publication\n\nBio: Sarah Köster\, studied ph
 ysics at the University of Ulm and performed her PhD work at the Universit
 y of Ulm\, Boston University and the Max Planck Institute for Dynamics and
  Self-Organization\, Göttingen. She received her PhD from the University 
 of Göttingen in 2006. Her thesis was awarded the Berliner-Ungewitter-Prei
 s of the Göttingen physics faculty as well as the Otto-Hahn-Medaille of t
 he Max-Planck-Society. In 2008\, after two years of postdoctoral work at H
 arvard University with David Weitz\, she returned to Göttingen as a junio
 r professor. In 2010 she was awarded the Helene-Lange-Preis of the EWE-Fou
 ndation. In 2011 she was promoted to a tenured W2 professor in the faculty
  of physics of the University of Göttingen\, where she leads the research
  group Nanoscale Imaging of Cellular Dynamics.\n 
LOCATION:MXF 1 https://plan.epfl.ch/?room==MXF%201
STATUS:CONFIRMED
END:VEVENT
END:VCALENDAR